Glibenclamide | 10238-21-8

Description :

Overview of Glibenclamide

Glibenclamide is a pharmaceutical-grade synthetic compound supplied as an active pharmaceutical ingredient (API) and classified under sulfonylurea antidiabetic agents. It is widely used in the manufacture of oral hypoglycaemic drug products intended for glycaemic control formulations.

In pharmaceutical manufacturing, Glibenclamide is valued for its well-characterised chemical profile, consistent batch performance, and suitability for oral solid dosage forms. It is produced under controlled GMP conditions to meet pharmacopeial standards for purity, potency, and identity.

As a pharma chemical, Glibenclamide is handled exclusively within licensed pharmaceutical manufacturing, formulation, and research facilities.

Applications of Glibenclamide

Pharmaceutical API Use

Glibenclamide is used as an active pharmaceutical ingredient in the manufacture of oral antidiabetic formulations. It is incorporated into tablets and combination products where controlled dose accuracy and bioavailability are required.

In antidiabetic API portfolios, Glibenclamide is commonly positioned alongside Metformin Hydrochloride, Gliclazide, and Glimepiride for diabetes-related product development.

Finished Dosage Form Manufacturing

Glibenclamide is used in the production of oral solid dosage forms, particularly tablets, where precise blending, content uniformity, and stability are essential. It is also formulated in fixed-dose combination products with other antidiabetic agents.

Manufacturing is carried out under GMP-compliant conditions due to its pharmacological potency and regulatory classification.

Pharmaceutical Research & Reference Use

Glibenclamide is used as a standard reference in research on pharmaceuticals, quality control tests, and analytical method validation. It is used in studies of dissolution, stability testing, and comparison profiling of sulfonylurea-based compounds.

In research environments, it may be referenced alongside Tolbutamide and Chlorpropamide for sulfonylurea comparison studies.

Safety & Handling Guidelines

• Keep it in a cool, humid, dry, and well-controlled space
• Guard against moisture and light
• Make sure containers are tightly sealed and clearly labeled
• Avoid contact with the air or direct contact with API powder
• Use appropriate personal protective equipment
• Handle only in regulated pharmaceutical manufacturing areas
• Dispose of waste according to pharmaceutical regulatory guidelines
  
  
  

Where to Buy Glibenclamide?

Glibenclamide Manufacturer

Glibenclamide is manufactured for pharmaceutical use under strict GMP conditions to ensure consistent quality, chemical purity, and regulatory compliance.

Glibenclamide Supplier & Distributor

The pharmaceutical-grade Glibenclamide API is offered in a compliant package that is suitable for licensed pharmaceutical companies or a formulation unit. As a supplier of pharmaceutical chemicals and distributor, Chemicalbull Pvt. Ltd. ensures secure sourcing through COA, MSDS, and documents for regulatory compliance.

MSDS for Glibenclamide

This MSDS for Glibenclamide includes detailed information on chemicals, safety handling techniques, specifications for storage and exposure control, and emergency response protocols. It is recommended to review it prior to any manufacturing or laboratory handling.

Frequently Asked Questions (FAQs)

1. What is Glibenclamide?
   

   Glibenclamide is a synthetic sulfonylurea compound supplied as an active pharmaceutical ingredient and used in the manufacture of oral antidiabetic drug formulations.
   
   

2. What is Glibenclamide used for?
   

   Glibenclamide is used as an API in pharmaceutical manufacturing for products intended to support blood glucose regulation in diabetes-related therapies.
   
   

3. Is Glibenclamide the same as Glyburide?
   

   Yes, Glibenclamide and Glyburide refer to the same chemical compound. Glibenclamide is the internationally used name, while Glyburide is commonly used in certain regional markets.
   
   

4. What is the difference between Metformin and Glibenclamide?
   

   Metformin and Glibenclamide differ in chemical class and formulation role. Metformin is a biguanide compound, while Glibenclamide is a sulfonylurea derivative. Both are used as APIs in antidiabetic formulations but function through different biochemical pathways.
   
   

5. What are the side effects of Glibenclamide?
   

   Side effects are associated with finished dosage forms and may include hypoglycaemia and gastrointestinal effects, which are managed through controlled dosing and medical supervision.