Gliclazide | 21187-98-4

Description :

Overview of Gliclazide

Glibenclamide is a synthetic pharmaceutical-grade chemical that is available with the designation of active pharmaceutical component (API) and classified as a sulfonylurea anti-diabetic agent. It is extensively used for the manufacturing of hypoglycaemic oral drug products designed for formulations to control glycaemic levels.

In pharmaceutical manufacturing, Gliclazide is valued for its selective pharmacological profile, consistent chemical behaviour, and suitability for modified-release and immediate-release oral dosage forms. It is produced under GMP-compliant conditions to meet pharmacopeial standards for purity, potency, and identity.

As a pharma chemical, Gliclazide is handled exclusively within licensed pharmaceutical manufacturing, formulation, and research facilities.

Applications of Gliclazide

Pharmaceutical API Use

Gliclazide is used as an active pharmaceutical ingredient in the manufacture of oral antidiabetic formulations, including conventional tablets and modified-release products. It supports formulation strategies requiring controlled release and stable glycaemic response.

In antidiabetic API portfolios, Gliclazide is commonly positioned alongside Metformin Hydrochloride, Glibenclamide, and Glimepiride for diabetes-focused product development.

Finished Dosage Form Manufacturing

Glibenclamide is used for the manufacture of oral dosage forms, notably tablets, where precise mixing consistency, content homogeneity, and stability are crucial. It can also be found in fixed-dose products that combine other anti-diabetic agents.

Manufacturing is carried out under strict GMP conditions due to its pharmacological potency and regulatory classification.

Pharmaceutical Research & Reference Use

Gliclazide is utilised as a reference compound in pharmaceutical research, analytical method development, and quality control testing. It is employed in dissolution studies, bioequivalence evaluation, and comparative sulfonylurea profiling.

In research environments, it may be referenced alongside Tolbutamide and Chlorpropamide for sulfonylurea class comparison.

Safety & Handling Guidelines

• Keep it in a cool, humid, dry, and well-controlled space
• Guard against moisture and light
• Make sure containers are tightly sealed and clearly labeled
• Avoid contact with the air or direct contact with API powder
• Wear appropriate personal protective equipment
• Handle only in regulated pharmaceutical manufacturing areas
• Dispose of waste according to pharmaceutical regulatory guidelines
  
  
  

Where to Buy Gliclazide?

Gliclazide Manufacturer

Glibenclamide is produced to be used in pharmaceuticals using rigorous GMP conditions to ensure consistency in high-quality, purity of the chemical, and compliance with regulations.

Gliclazide Supplier & Distributor

Pharmaceutical-grade Gliclazide API is supplied in compliant packaging suitable for licensed pharmaceutical manufacturers and formulation units. As a pharmaceutical chemicals supplier and distributor, Chemicalbull Pvt. Ltd. supports reliable sourcing with COA, MSDS, and regulatory documentation.

MSDS for Gliclazide

The MSDS for Gliclazide provides detailed information on chemical hazards, safe handling practices, storage requirements, exposure controls, and emergency response procedures. It should be reviewed prior to manufacturing or laboratory handling.

Frequently Asked Questions (FAQs)

1. What is Gliclazide?
   

   Gliclazide is a second-generation sulfonylurea compound supplied as an active pharmaceutical ingredient and used in the manufacture of oral antidiabetic drug formulations.
   
   

2. What is Gliclazide used for?
   

   Gliclazide is used as an API in pharmaceutical manufacturing for formulations intended to support blood glucose control in diabetes-related therapies.
   
   

3. What is the mechanism of action of Gliclazide?
   

   Gliclazide works by stimulating insulin release from pancreatic beta cells through selective interaction with sulfonylurea receptors, resulting in controlled glucose-lowering activity when formulated into finished products.
   
   

4. What is the difference between Gliclazide and Metformin?
   

   Gliclazide and Metformin differ in chemical class and formulation role. Gliclazide is a sulfonylurea derivative, while Metformin is a biguanide compound. Both are used as APIs in antidiabetic formulations but act through different biochemical mechanisms.
   
   

5. What is the difference between Glimepiride and Gliclazide?
   

   Glimepiride and Gliclazide are both sulfonylurea compounds, but they differ in molecular structure, potency, and formulation behaviour. These differences influence dose strength and product positioning in pharmaceutical manufacturing.