Dimethyl Fumarate | 624-49-7

Description :

Overview of Dimethyl Fumarate

Dimethyl Fumarate can be described as an immunomodulatory medication used to treat chronic forms of multiple sclerosis (MS) as well as moderate to severe plaque Psoriasis. The drug is known for its anti-inflammatory properties and neuroprotective effects. Dimethyl Fumarate is widely utilised in dermatology and neurology to treat diseases.

This API appears as a white to off-white crystalline powder with good stability under controlled storage conditions. Its mechanism—activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway—provides antioxidant effects, modulates immune response, and reduces inflammatory damage in MS and psoriasis.

Related products include Glatiramer Acetate, Interferon Beta, Methotrexate, and other immunomodulatory agents used to manage autoimmune and neurological diseases.

Applications of Dimethyl Fumarate

Pharmaceutical API

• Used in disease-modifying therapy for multiple sclerosis
• Effective in treating relapsing-remitting MS
• Applied in moderate-to-severe plaque psoriasis treatment
• Provides neuroprotection and anti-inflammatory effects

Formulation Development

• Used in delayed-release (enteric-coated) capsules
• Requires gastro-resistant coating to minimise GI side effects
• Offers good bioavailability with a specialised formulation
• Stable in properly formulated dosage forms

Neurological & Dermatological Treatment

• Reduces relapse rate and disability progression in MS
• Improves skin lesions and quality of life in psoriasis
• Well-tolerated alternative to injectable MS therapies
• Convenient oral dosing regimen

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Store in a cool, dry place away from light and moisture
• Follow COA and MSDS instructions strictly

Where to Buy Dimethyl Fumarate?

Dimethyl Fumarate Manufacturer

ChemicalBull supplies high-purity Dimethyl Fumarate API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Dimethyl Fumarate Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is the structure of Dimethyl Fumarate?
   

   Dimethyl Fumarate has the molecular formula C₆H₈O₄ and is the dimethyl ester of fumaric acid with a trans-configuration double bond.
   
   

2. What is Dimethyl Fumarate used for?
   

   It is used for treating relapsing forms of multiple sclerosis and moderate-to-severe plaque psoriasis.
   
   

3. What is another name for Dimethyl Fumarate?
   

   Dimethyl Fumarate is also known as DMF or by brand names such as Tecfidera (for MS) and Skilarence (for psoriasis).
   
   

4. How does Dimethyl Fumarate work?
   

   It activates the Nrf2 antioxidant pathway, reducing oxidative stress and modulating immune cell function to decrease inflammation and neurological damage.
   
   

5. Is Dimethyl Fumarate stable for oral formulation?
   

   Yes, when formulated with an enteric coating for delayed release, it maintains excellent stability and efficacy.