Methotrexate | 59-05-2
Cas No :
59-05-2
Form :
Powder
Molecular Weight :
454.45 G/Mol
Molecular Formula :
C20H22N8O5
Boiling Point :
360 °C
Melting Point :
201 °C
Flash Point :
300 °C
Solubility :
Sparingly Soluble In Water; Soluble In Methanol And Dmso
Quality Standards :
Ip
Description :
Overview of Methotrexate
Methotrexate is a widely used antimetabolite and antifolate pharmaceutical API primarily used in the treatment of cancer, autoimmune disorders, and inflammatory diseases. It works by inhibiting the enzyme dihydrofolate reductase (DHFR), which slows down cell growth and reduces immune system overactivity.
Commonly used in oncology, rheumatoid arthritis, psoriasis, and ectopic pregnancy management, Methotrexate is formulated in tablets, injections, and oral solutions. It is often processed with ChemicalBull excipients such as Lactose Anhydrous, Sodium Hydroxide, Sodium Chloride, Magnesium Stearate, and Benzyl Alcohol, depending on the dosage form.
Applications of Methotrexate
Oncology (Cancer Treatment)
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Used in chemotherapy for leukemia, breast cancer, lung cancer, and lymphoma
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Applied in high-dose therapeutic regimens
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Often accompanied by folinic acid (leucovorin) rescue therapy
Autoimmune & Inflammatory Diseases
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Widely prescribed for rheumatoid arthritis
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Effective in severe psoriasis and psoriatic arthritis
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Used in inflammatory bowel disease (IBD) management
Gynecology
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Used in the medical management of ectopic pregnancy
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Helps inhibit abnormal cell growth
Research & Clinical Development
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Used in anti-cancer studies
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Applied in immunology and cell-division research
Safety & Handling Guidelines
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Store in a dry, cool, and well-ventilated area
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Avoid inhalation and direct skin contact
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Handle with gloves, mask, and protective eyewear
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Follow MSDS for toxicity, first aid, and disposal procedures
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Cytotoxic handling precautions recommended
Where to Buy Methotrexate?
Methotrexate Manufacturer
Manufactured under strict GMP and oncology-grade standards ensuring high purity, stability, and safety.
Methotrexate Supplier & Distributor
ChemicalBull supplies bulk Methotrexate API to pharmaceutical companies, formulation units, and research laboratories. COA, MSDS, and export-grade packaging available.
MSDS for Methotrexate
MSDS includes:
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Hazard identification (cytotoxic API)
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Handling precautions
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Exposure control
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Stability & reactivity information
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First-aid measures
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Proper disposal guidelines
Frequently Asked Questions (FAQs)
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What is Methotrexate used for?
It is used for cancer treatment, rheumatoid arthritis, psoriasis, and certain autoimmune diseases. -
Is Methotrexate a chemotherapy drug?
Yes, it is an antimetabolite used in chemotherapy regimens. -
Do you supply Methotrexate in bulk?
Yes, ChemicalBull supplies Methotrexate API in bulk with COA, MSDS, and export-ready packaging.
