2,2,2-Trifluoroethyl Trifluoromethanesulfonate | 6226-25-1

Description :

Overview of 2,2,2-Trifluoroethyl Trifluoromethanesulfonate

2,2,2-Trifluoroethyl Trifluoromethanesulfonate (CAS: 6226-25-1) is a highly reactive triflate ester widely used in pharmaceutical synthesis, fluorinated compound production, and advanced organic chemistry reactions. It typically appears as a colourless to pale yellow liquid and is known for its excellent leaving group ability, making it valuable in nucleophilic substitution and fluorination-related reactions.

This compound is commonly used as a trifluoroethylating agent for introducing fluorinated functional groups into complex organic molecules. Fluorinated intermediates play a crucial role in modern drug design, agrochemical development, and high-performance materials due to their enhanced metabolic stability, lipophilicity, and chemical resistance.

In advanced organic synthesis, reagents such as Trifluoromethanesulfonic Anhydride, Trifluoroacetic Anhydride, and Diethylaminosulfur Trifluoride (DAST) are also used for fluorination, activation reactions, and preparation of fluorinated intermediates in pharmaceutical and speciality chemical manufacturing.

Applications of 2,2,2-Trifluoroethyl Trifluoromethanesulfonate

Pharmaceutical Intermediates

2,2,2-Trifluoroethyl Trifluoromethanesulfonate is widely used in API synthesis and fluorinated drug intermediates.

• Used for introducing trifluoroethyl functional groups into drug molecules

• Supports synthesis of fluorinated pharmaceutical intermediates

• Improves metabolic stability and pharmacokinetic properties

• Applied in modern medicinal chemistry

Agrochemical Synthesis

Fluorinated compounds play a major role in crop-protection chemistry.

• Used in synthesis of fluorinated herbicide and pesticide intermediates

• Enhances chemical stability and biological activity

• Supports development of high-performance agrochemicals

Specialty Fluorochemical Manufacturing

The compound is useful in high-value fluorinated chemical production.

• Used as a trifluoroethylation reagent

• Supports functional group modification of organic molecules

• Applied in fine chemical manufacturing

Organic Synthesis & Chemical Research

This reagent is widely used in advanced organic chemistry reactions.

• Suitable for nucleophilic substitution reactions

• Used in fluorinated building block synthesis

• Applied in academic and industrial R&D laboratories

Advanced Materials Development

Fluorinated molecules are essential in many high-performance materials.

• Used in fluorinated polymer and material synthesis

• Supports production of specialty coatings and functional materials

• Improves chemical resistance and thermal stability

Safety & Handling Guidelines

• Handle with protective gloves, goggles, and lab safety equipment

• Avoid direct contact with skin and eyes

• Use only in well-ventilated laboratory or industrial environments

• Store in tightly sealed containers away from moisture

• Keep away from strong bases, oxidizers, and reactive chemicals

• Follow COA and MSDS instructions carefully

Where to Buy 2,2,2-Trifluoroethyl Trifluoromethanesulfonate?

2,2,2-Trifluoroethyl Trifluoromethanesulfonate Manufacturer

ChemicalBull supplies high-purity 2,2,2-Trifluoroethyl Trifluoromethanesulfonate suitable for pharmaceutical synthesis, fluorochemical production, and advanced organic reactions.

2,2,2-Trifluoroethyl Trifluoromethanesulfonate Supplier & Distributor

• Available in laboratory and industrial bulk packaging

• Suitable for fluorinated intermediate synthesis

• Ideal for pharmaceutical and specialty chemical manufacturing

• COA, MSDS, and technical documentation available

2,2,2-Trifluoroethyl Trifluoromethanesulfonate MSDS

• May cause skin and eye irritation

• Vapors may irritate the respiratory tract

• Avoid inhalation and prolonged exposure

• Store in cool, dry, and well-ventilated conditions

• Refer to complete MSDS for emergency and spill procedures

Frequently Asked Questions (FAQs)

1. What is the molecular formula of 2,2,2-Trifluoroethyl Trifluoromethanesulfonate?

   Molecular Formula: C₃H₂F₆O₃S
   Molecular Weight: 232.10 g/mol
   
   

2. What is 2,2,2-Trifluoroethyl Trifluoromethanesulfonate used for?

   It is mainly used as a trifluoroethylating reagent in pharmaceutical intermediates, fluorinated chemical synthesis, and advanced organic reactions.
   
   

3. Which industries use this chemical?

   Industries include pharmaceutical manufacturing, agrochemical production, specialty fluorochemicals, and chemical research laboratories.
   
   

4. Why are fluorinated intermediates important in pharmaceuticals?

   Fluorine atoms often improve drug stability, bioavailability, and biological activity, making fluorinated intermediates important in modern medicinal chemistry.
   
   

5. Is 2,2,2-Trifluoroethyl Trifluoromethanesulfonate hazardous?

   Yes, it can cause irritation and should be handled using proper PPE and safety procedures according to MSDS guidelines.