1-Chloroethyl Chloroformate | 50893-53-3
Cas No :
50893-53-3
Form :
Liquid
Molecular Weight :
142.95 G/Mol
Molecular Formula :
C3H4CL2O2
Boiling Point :
60 °C
Melting Point :
-40 °C
Flash Point :
-6 °C
Solubility :
Reacts With Water; Soluble In Organic Solvents
Description :
Overview of 1-Chloroethyl Chloroformate
1-Chloroethyl Chloroformate is a reactive chloroformate compound used in pharmaceutical synthesis, peptide chemistry, and as a protecting group reagent. Known for its use in introducing 1-chloroethoxycarbonyl (Cec) protecting groups, excellent reactivity with amines and alcohols, and applications in organic synthesis, this compound is widely used in pharmaceutical manufacturing, peptide synthesis, and specialty chemical production.
This compound appears as a colorless to pale yellow liquid with a pungent odor. Its chloroformate structure provides powerful acylating capability.
Related products include Benzyl Chloroformate, Ethyl Chloroformate, and other chloroformates used in pharmaceutical synthesis and protecting group chemistry.
Applications of 1-Chloroethyl Chloroformate
Pharmaceutical Synthesis
- Used in introducing the protecting groups
- Applied in pharmaceutical intermediate production
- Used in peptide synthesis
Peptide Chemistry
- Used as an N-protecting group in peptide synthesis
- Applied in solid-phase peptide synthesis
- Used in protecting amino groups
Industrial Chemical Synthesis
- Used in producing specialty chemicals
- Applied in organic synthesis reactions
- Used in manufacturing chemical intermediates
Safety & Handling Guidelines
- HIGHLY REACTIVE and CORROSIVE—severe hazard
- LACHRYMATORY—causes severe tearing
- Reacts violently with water and alcohols
- Use only in a well-ventilated fume hood
- Wear full PPE, including respirator, gloves, and face shield
- Handle under anhydrous conditions
Where to Buy 1-Chloroethyl Chloroformate?
1-Chloroethyl Chloroformate Manufacturer
ChemicalBull supplies high-purity 1-Chloroethyl Chloroformate for pharmaceutical and research applications.
1-Chloroethyl Chloroformate Supplier & Distributor
- Available in controlled quantities for pharmaceutical and research use
- High-purity grades (97%, 98%)
- Special moisture-resistant packaging under inert gas
- COA, MSDS, and comprehensive safety documentation provided
MSDS
Includes comprehensive lachrymatory and reactivity warnings.
Frequently Asked Questions (FAQs)
-
What is 1-Chloroethyl Chloroformate used for?
Used in introducing Cech protecting groups, peptide synthesis, and pharmaceutical intermediate production. -
What is the molecular formula?
Molecular formula: C₃H₄Cl₂O₂ with molecular weight 142.97 g/mol. -
What is a protecting group?
1-Chloroethoxycarbonyl protecting group; removed under mild conditions, making it useful in peptide synthesis.
