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Benzyl Chloroformate

Benzyl Chloroformate | 501-53-1

Cas No :

501-53-1

Form :

Liquid

Molecular Weight :

170.59 G/Mol

Molecular Formula :

C8H7CLO2

Boiling Point :

103 °C

Melting Point :

-18 °C

Flash Point :

92 °C

Solubility :

Acetonitrile (Slightly), Chloroform, Ethyl Acetate (Slightly)

Description :

Overview of Benzyl Chloroformate

 

Benzyl Chloroformate (Cbz-Cl or Z-Cl) is a key reagent used in industrial organic synthesis to introduce the benzyloxycarbonyl (Cbz/Z) protecting group onto amines in peptide and API synthesis. This chemical appears as a colorless to pale yellow liquid with a pungent odor. CAS No. 501-53-1, molecular weight 170.59 g/mol. Related products include Phosphorus Pentachloride, Potassium Ethyl Xanthate, and Pivalic Acid, commonly used in chlorination, xanthate-based flotation, and fine chemical synthesis.

 

 

Applications of Benzyl Chloroformate

 

Pharmaceutical API

 

  • Essential for amine protection in peptide and small-molecule API synthesis
  • Used in total synthesis and protecting group strategies

 

Formulation Development

 

  • Utilized in multi-step organic synthesis as well as scale-up

 

Gastrointestinal Treatment

 

  • Not therapeutic. Protects groups with a group reagent

 

 

Safety & Handling Guidelines

 

  • Do not inhale or come into contact with (corrosive and lachrymatory)
  • Wear goggles, gloves, and protective clothing inside the fume hood.
  • Place in a dry, cool area in an atmosphere of absolute silence
  • Use the COA as well as the MSDS directions strictly.

 

 

Where to Buy Benzyl Chloroformate?

 

Benzyl Chloroformate Manufacturer

 

ChemicalBull offers high-purity Benzyl chloroformate that meets the requirements of reagents.

 

Benzyl Chloroformate Supplier & Distributor

 

  • In bulk, available to synthesizer units
  • Pure and high-purity materials to be used in research and production
  • COA MSDS as well as regulatory documentation available

 

 

MSDS

 

With detailed safety tips, including hazard identification as well as storage guidelines.

 

 

Frequently Asked Questions (FAQs)

 

  1. What is Benzyl Chloroformate used for?

    It is used to introduce the Cbz protecting group in peptide and API synthesis.

  2. Is Benzyl Chloroformate stable for industrial formulation?

    Stable under dry conditions; reactive with water.

  3. What is the CAS No. of Benzyl Chloroformate?

    The CAS No. of Benzyl Chloroformate is 501-53-1.