Tolvaptan | 150683-30-0

Description :

Overview of Tolvaptan

Tolvaptan is a specific vasopressin V2-receptor antagonist, which is utilized to treat hypernatremia and to slow the growth of kidney cysts in the autosomal dominant kidney disorder (ADPKD). The drug is known for its effects on the aquaretic system (water excretion with no loss of electrolytes). Tolvaptan is widely utilized to manage electrolyte and fluid imbalances, as well as a treatment for disease modification for ADPKD.

This API appears as a white to off-white crystalline powder with poor water solubility. Its mechanism—selective antagonism of V2 receptors in renal collecting ducts—blocks vasopressin action, preventing water reabsorption and promoting free water excretion, thereby increasing serum sodium in hyponatremia and reducing cyst growth in ADPKD.

Related products include Conivaptan, other vaptans, and diuretics used in fluid balance management and renal disease treatment.

Applications of Tolvaptan

Pharmaceutical API

• Used in treating clinically significant hypervolemic/euvolemic hyponatremia
• Applied to heart failure patients with hyponatremia
• Used for SIADH (syndrome of inappropriate ADH secretion)
• Applied to slow kidney function decline in ADPKD
• Used in cirrhosis with hyponatremia
• Investigational use in other cystic kidney diseases

Formulation Development

• Used in immediate-release tablets
• Multiple strengths for different indications
• Lower doses (15-60 mg) for hyponatremia
• Higher doses (45-120 mg/day split dose) for ADPKD
• Lipophilic—formulation challenges addressed
• Stable in solid dosage forms

Renal & Cardiovascular Treatment

• Enhances the amount of sodium in your blood without limiting fluid intake
• Promotes free water excretion (aquaresis)
• Therapy to treat the disease in ADPKD
• Enhances the symptoms of hyponatremia
• Could reduce hospitalizations for heart failure
• requires constant monitoring and titration of doses

Safety and Handling Guidelines

• Do not inhale fine powder
• Make sure you wear gloves, goggles, or protective clothing while handling
• Place in a dry, cool area, protected from humidity
• Be sure to follow COA and MSDS directions strictly and

Where can I buy Tolvaptan?

Tolvaptan Manufacturer

ChemicalBull supplies high-purity Tolvaptan API, meeting IP/EP/USP quality standards for pharmaceutical formulations.

Tolvaptan Supplier & Distributor

• It is available in bulk packing to form units for formulation
• High-purity and stable for production and research
• COA MSDS, along with other documents for regulatory purposes, is provided.

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Tolvaptan used for?
   

   Used for treating hyponatremia (low sodium) in heart failure, SIADH, cirrhosis, and for slowing kidney function decline in autosomal dominant polycystic kidney disease.
   
   

2. How does Tolvaptan work?
   

   Selectively blocks V2 vasopressin receptors in kidney collecting ducts, preventing water reabsorption while preserving electrolytes, leading to free water excretion.
   
   

3. What is the difference between Tolvaptan and traditional diuretics?
   

   Tolvaptan causes aquaresis (water loss without electrolyte loss) vs. traditional diuretics, causing natriuresis/diuresis (water and sodium loss); useful when sodium preservation is needed.