Sulphamethoxazole | 723-46-6

Description :

Overview of Sulphamethoxazole

Sulphamethoxazole (Sulfamethoxazole) is a sulfonamide antibiotic used in combination with trimethoprim for treating various bacterial infections. Known for its broad-spectrum antibacterial activity and synergistic effect with trimethoprim, Sulphamethoxazole is widely used in urinary tract infections, respiratory infections, and opportunistic infections in immunocompromised patients.

This API appears as a white to off-white crystalline powder with limited water solubility. Its mechanism—competitive inhibition of bacterial dihydropteroate synthase—prevents folic acid synthesis in bacteria, providing bacteriostatic activity that becomes bactericidal when combined with trimethoprim.

Related products include Trimethoprim, other sulfonamides, and broad-spectrum antibiotics used in various bacterial infection treatments.

Applications of Sulphamethoxazole

Pharmaceutical API

• Used in combination with trimethoprim (co-trimoxazole/TMP-SMX)
• Effective against urinary tract infections
• Applied in respiratory tract infections (bronchitis, pneumonia)
• Used for Pneumocystis jirovecii pneumonia (PCP) prophylaxis and treatment
• Applied to toxoplasmosis and nocardiosis
• Used in traveler's diarrhea and other GI infections

Formulation Development

• U is sed on tablet computers (standard as well as double-strength)
• Suspension for oral use formulations
• Formulations that can be injected to treat extremely severe illnesses
• Fixed-dose mixture that includes trimethoprim (5:1 ratio that is typical)
• Pediatric formulations available
• It is usable in both solid and the liquid form.

Infectious Medicine Treatment

• Therapy for first-line in uncomplicated UTIs
• PCP prophylaxis in HIV/AIDS patients
• Alternative for MRSA skin infections
• It is used for prophylaxis of chronic granulomatous diseases.
• Wide coverage of community acquired diseases
• Cost-effective antibiotic option

Safety and Guidelines for Handling

• Beware of inhaling fine powder
• Wear gloves, goggles and other protective gear while handling
• Place in a dry, cool area, away from direct sunlight
• Be sure to follow COA and MSDS directions completely

Where to Buy Sulphamethoxazole?

Sulphamethoxazole Manufacturer

ChemicalBull supplies high-purity Sulphamethoxazole API, meeting IP/EP/USP quality standards for pharmaceutical formulations.

Sulphamethoxazole Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Sulphamethoxazole used for?
   

   Used (typically with trimethoprim) for UTIs, respiratory infections, PCP prophylaxis/treatment, skin infections, GI infections, and various opportunistic infections.
   
   

2. How does Sulphamethoxazole work?
   

   Inhibits bacterial dihydropteroate synthase, preventing folic acid synthesis; combined with trimethoprim (inhibits the next step), provides synergistic bactericidal activity.
   
   

3. What is the typical dosage?
   

   Varies by indication; UTI: 800/160 mg (SMX/TMP) twice daily; PCP treatment: higher doses; prophylaxis: lower doses 3x/week or daily.