Sildenafil Citrate | 171599-83-0

Description :

Overview of Sildenafil Citrate

Sildenafil Citrate is a phosphodiesterase five (PDE5) inhibitor for the treatment of Erectile dysfunction (ED) as well as the condition of pulmonary arterial hypertension (PAH). It is known for its specific suppression of the PDE5 enzyme as well as vasodilatory effects. Sildenafil Citrate is widely employed in the treatment of sexual health as well as cardiovascular treatment for the treatment of pulmonary hypertension.

This API appears as a white to off-white crystalline powder with characteristic properties and limited water solubility. Its mechanism—selective inhibition of PDE5 enzyme in smooth muscle—increases cyclic GMP levels, leading to smooth muscle relaxation and vasodilation in the corpus cavernosum and pulmonary vasculature.

Related products include Tadalafil, Vardenafil, Avanafil, and other PDE5 inhibitors used in erectile dysfunction and pulmonary arterial hypertension treatment.

Applications of Sildenafil Citrate

Pharmaceutical API

• Used in erectile dysfunction medications
• Effective in treating pulmonary arterial hypertension (PAH)
• Applied to male sexual dysfunction across various etiologies
• Used for PAH in both adults and pediatric patients
• Improves exercise capacity in PAH patients
• Off-label uses in altitude sickness and Raynaud's phenomenon

Formulation Development

• Used in immediate-release tablets (25, 50, 100 mg for ED)
• Available in oral suspension for pediatric PAH
• Injectable formulation for acute PAH management
• Film-coated tablets for improved stability and palatability
• Stable in properly formulated solid and liquid dosage forms
• Various strengths for different indications

Therapeutic Treatment

• Provides effective treatment for ED with a rapid onset (30-60 minutes)
• Improves hemodynamics in pulmonary arterial hypertension
• Duration of action: 4-6 hours for ED indication
• Improves the quality of life in both ED and PAH patients
• Well-established safety and efficacy profile
• Requires sexual stimulation for the ED effect (not an aphrodisiac)

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Potent cardiovascular agent—handle with appropriate care
• Store in a cool, dry place protected from light and moisture
• Follow COA and MSDS instructions strictly

Where to Buy Sildenafil Citrate?

Sildenafil Citrate Manufacturer

ChemicalBull supplies high-purity Sildenafil Citrate API, meeting IP/EP/USP quality standards for pharmaceutical formulations.

Sildenafil Citrate Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What are the uses of Sildenafil Citrate tablets?
   

   Sildenafil Citrate tablets are used for treating erectile dysfunction in men and pulmonary arterial hypertension (PAH) in both adults and children.
   
   

2. What is Sildenafil Citrate used for?
   

   It is used for erectile dysfunction treatment, pulmonary arterial hypertension management, and off-label for altitude sickness and certain cardiovascular conditions.
   
   

3. How does Sildenafil Citrate work?
   

   It inhibits the PDE5 enzyme, preventing the breakdown of cyclic GMP, which leads to smooth muscle relaxation and increased blood flow to specific tissues (penile tissue for ED, pulmonary vessels for PAH).