Quinine Sulphate
Description :
Overview of Quinine Sulphate
Quinine Sulphate is an antimalarial alkaloid extracted from the bark of cinchona, and utilized to treat malaria and stop leg cramps that occur at night. Known for its effectiveness against chloroquine-resistant malaria and muscle relaxant properties, Quinine Sulphate is widely used in tropical medicine and as a therapeutic agent for severe cramping conditions.
This API appears as a white crystalline powder with a characteristic bitter taste and fluorescence under UV light. Its mechanism—interference with parasite heme detoxification and DNA function, as well as effects on muscle membrane excitability—provides potent antimalarial activity and cramp relief.
Related products include Quinine Hydrochloride, Chloroquine Phosphate, Artemether, and other antimalarial compounds used in malaria treatment protocols.
Applications of Quinine Sulphate
Pharmaceutical API
- Used in oral antimalarial medications for uncomplicated and severe malaria
- Effective against chloroquine-resistant Plasmodium falciparum
- Applied in the treatment and prevention of nocturnal leg cramps
- Used in combination with antimalarial therapy
- Second-line treatment when other antimalarials are contraindicated
Formulation Development
- Used in tablets, capsules, and oral suspensions
- Requires taste-masking due to extreme bitterness
- Film-coating helps improve palatability
- Light-sensitive—requires amber packaging
- Often combined with other antimalarials for synergistic effects
- Stable in solid dosage forms with proper protection
Antimalarial & Therapeutic Treatment
- Provides effective treatment for malaria in endemic regions
- Relieves painful and disruptive leg cramps
- Important backup when resistance develops to first-line drugs
- Requires careful dosing and monitoring (narrow therapeutic index)
- Available globally as an essential medicine
Safety & Handling Guidelines
- Avoid inhalation of fine powder
- Use gloves, goggles, and protective clothing during handling
- Protect from light—use amber containers
- Store in a cool, dry place away from light and moisture
- Follow COA and MSDS instructions strictly
Where to Buy Quinine Sulphate?
Quinine Sulphate Manufacturer
ChemicalBull supplies high-purity Quinine Sulphate API that meets IP/EP/USP quality standards for pharmaceutical formulations.
Quinine Sulphate Supplier & Distributor
- Available in bulk packing for formulation units
- Stable and high-purity grade for research and production
- COA, MSDS, and regulatory documents provided
MSDS
Includes detailed safety instructions, hazard identification, and storage guidelines.
Frequently Asked Questions (FAQs)
-
What is the Quinine Sulphate structure?
Quinine Sulphate is the sulphate salt of quinine alkaloid with molecular formula (C₂₀H₂₄N₂O₂)₂·H₂SO₄·2H₂O (dihydrate form). -
What is Quinine Sulphate injection used for?
While Quinine Sulphate can be formulated for injection, quinine hydrochloride or dihydrochloride is more commonly used parenterally for severe malaria requiring IV treatment. -
What is Quinine Sulphate used for?
It is used to treat uncomplicated and severe malaria, to prevent and treat nocturnal leg cramps, and as an alternative antimalarial when resistance or contraindications exist. -
How does Quinine Sulphate differ from Quinine Hydrochloride?
Both contain the same quinine base but different salt forms; sulphate is preferred for oral use, while hydrochloride has better aqueous solubility for parenteral use. -
Is Quinine Sulphate still used for malaria?
Yes, it remains an important antimalarial, especially for chloroquine-resistant malaria and in areas where artemisinin-based therapies are unavailable.
