Pralidoxime Iodide | 94-63-3

Description :

Overview of Pralidoxime Iodide

Pralidoxime Iodide is an oxime-based cholinesterase reactivator used as an antidote for organophosphate poisoning and nerve agent exposure. Known for its ability to reverse neuromuscular blockade caused by cholinesterase inhibitors, Pralidoxime Iodide is widely used in emergency medicine and military applications for treating acute organophosphate and carbamate poisoning.

This API appears as a white to off-white crystalline powder with good water solubility and stability. Its mechanism—reactivation of acetylcholinesterase enzyme by removing the phosphate group—restores standard neuromuscular transmission and reverses the toxic effects of organophosphate compounds.

Related products include Pralidoxime Chloride, Atropine Sulfate, Obidoxime, and other antidotes used in toxicological emergencies and chemical warfare agent exposure.

Applications of Pralidoxime Iodide

Pharmaceutical API

• Used in antidote formulations for organophosphate poisoning
• Effective in treating pesticide poisoning (e.g., malathion, parathion)
• Applied in nerve agent exposure treatment (military/chemical warfare)
• Used in combination with atropine for comprehensive treatment
• Reverses the nicotinic effects of organophosphate toxicity

Formulation Development

• Used in injectable solutions for emergency administration
• Available in lyophilised powder for reconstitution
• Requires rapid availability in emergency settings
• Stable in properly formulated injectable preparations
• Often packaged in emergency antidote kits

Emergency & Toxicological Treatment

• It is essential to administer the treatment quickly for effective treatment
• R activates acetylcholinesterase on the junction between neuromuscular cells
• Inverts muscle weakness as well as respiratory insufficiency
• It is most effective when it is administered soon following exposure
• It is used in agriculture and industrial poisoning instances

Safety & Handling Guidelines

• Beware of inhaling fine powder
• Make sure you wear goggles, gloves, and protective clothing when handling
• Keep it in a dry, cool space away from light and humidity
• Be sure to follow COA and MSDS guidelines completely
• Use as a powerful drug agent

Where to Buy Pralidoxime Iodide?

Pralidoxime Iodide Manufacturer

ChemicalBull supplies high-purity Pralidoxime Iodide API, meeting IP/EP/USP quality standards for pharmaceutical formulations.

Pralidoxime Iodide Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for emergency medicine production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Pralidoxime Iodide used for?
   

   It is used as an antidote for organophosphate poisoning, including pesticide exposure and nerve agent toxicity.
   
   

2. How does Pralidoxime work?
   

   It reactivates the acetylcholinesterase enzyme by cleaving the phosphate-enzyme bond, restoring standard nerve signal transmission.
   
   

3. What is the difference between Pralidoxime Iodide and Pralidoxime Chloride?
   

   Both contain the same active pralidoxime cation but different anions (iodide vs. chloride); they have similar efficacy with minor pharmacokinetic differences.