Miconazole Nitrate | 22832-87-7

Description :

Overview of Miconazole Nitrate

Miconazole Nitrate is an imidazole with a broad spectrum antifungal drug used to treat minor fungal conditions, like candidiasis, dermatophytosis and tinea-related infections. It is renowned for its powerful antifungal action against yeasts and dermatophytes. Miconazole Nitrate is used extensively in dermatological, gynaecological and oral preparations.

This API appears as a white to slightly yellowish crystalline powder with good stability under controlled storage conditions. Its mechanism—inhibition of fungal cytochrome P450-dependent 14α-lanosterol demethylase—disrupts ergosterol synthesis in fungal cell membranes, thereby increasing membrane permeability and causing cell death.

Related products include Imidazole, Clotrimazole, Econazole Nitrate, Ketoconazole, and other azole antifungal agents used in topical and systemic antifungal therapy.

Applications of Miconazole Nitrate

Pharmaceutical API

• Used in topical and systemic antifungal medications
• Effective against dermatophytes, yeasts (Candida species), and some bacteria
• Treats tinea pedis, tinea cruris, tinea corporis, and cutaneous candidiasis
• Used for vulvovaginal candidiasis (yeast infections)
• Applied in oral thrush and denture stomatitis treatment

Formulation Development

• Used in creams, ointments, powders, sprays, and vaginal suppositories
• Available in oral gels for oral candidiasis
• Combined with hydrocortisone for anti-inflammatory effects
• May be combined with Ibuprofen in formulations for pain and inflammation
• Offers good skin penetration and local retention
• Stable in various topical and mucosal formulation bases

Dermatological & Gynaecological Treatment

• Provides rapid relief from fungal skin and mucosal infections
• Reduces itching, inflammation, and skin lesions
• Once or twice daily application regimen
• Suitable for various anatomical sites (skin, vaginal, oral)
• Effective against mixed fungal-bacterial infections

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Store in a cool, dry place away from light and moisture
• Follow COA and MSDS instructions strictly

Where to Buy Miconazole Nitrate?

Miconazole Nitrate Manufacturer

ChemicalBull supplies high-purity Miconazole Nitrate API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Miconazole Nitrate Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Miconazole Nitrate used for?
   

   It is used for treating fungal skin infections (athlete's foot, jock itch, ringworm), vaginal yeast infections, and oral thrush.
   
   

2. Is Miconazole Nitrate the same as Clotrimazole?
   

   No, while both are imidazole antifungals with similar mechanisms, they are different compounds with some variations in spectrum and formulations.
   
   

3. Can Miconazole Nitrate be used during pregnancy?
   

   Topical use is generally considered safe during pregnancy, but consult a healthcare provider, especially for vaginal products.