Diphenhydramine Hydrochloride | 147-24-0

Description :

Overview of Diphenhydramine Hydrochloride

Diphenhydramine Hydrochloride is a first-generation antihistamine used to treat allergic reactions, insomnia, and motion sickness, and as an antitussive. Known for its sedating properties and broad antihistaminic effects, Diphenhydramine Hydrochloride is widely used in over-the-counter and prescription formulations for allergy relief, sleep aids, and cold and cough medications.

This API appears as a white to off-white crystalline powder with excellent water solubility and stability under standard storage conditions. Its mechanism—antagonism of histamine H1 receptors with additional anticholinergic and sedative effects—provides relief from allergic symptoms, induces sleep, and suppresses the cough reflex.

Related products include Chlorpheniramine, Cetirizine, Promethazine, and other antihistamine agents used in allergy, sleep, and respiratory therapy.

Applications of Diphenhydramine Hydrochloride

Pharmaceutical API

• Used in antihistamines, sleep aids, and anti-motion sickness medications
• Effective in treating allergic rhinitis, urticaria, and allergic conjunctivitis
• Applied in the management of insomnia and sleep disturbances
• Used for motion sickness prevention and antiemetic therapy
• Acts as an antitussive in cough-cold formulations

Formulation Development

• Used in tablets, capsules, syrups, elixirs, and topical preparations
• Available in immediate-release and sustained-release formulations
• Used in combination products with analgesics like Ibuprofen or decongestants
• Injectable formulations available for acute allergic reactions
• Offers excellent stability in various dosage forms

Allergy & Sleep Treatment

• Offers quick relief from symptoms of allergies (sneezing or itching, eyes that are watery)
• It induces sedation to aid in the management of short-term insomnia
• Relieves nausea and vomiting resulting from motion sickness
• Formulations for topical use reduce itching caused by bites from insects and skin irritations
• is suitable for children as well as adult population

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Store in a cool, dry place away from light and moisture
• Follow COA and MSDS instructions strictly

Where to Buy Diphenhydramine Hydrochloride?

Diphenhydramine Hydrochloride Manufacturer

ChemicalBull supplies high-purity Diphenhydramine Hydrochloride API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Diphenhydramine Hydrochloride Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Diphenhydramine Hydrochloride used for?
   

   It is used to treat allergies, hay fever, common cold symptoms, insomnia, and motion sickness, and as a cough suppressant.
   
   

2. Is Diphenhydramine Hydrochloride safe for sleep?
   

   Yes, it is commonly used as an over-the-counter sleep aid, though it should be used short-term and may cause next-day drowsiness.
   
   

3. Can Diphenhydramine be combined with pain relievers?
   

   Yes, it is often combined with Ibuprofen or acetaminophen in formulations for nighttime pain relief with sleep aid benefits.