Diosmin | 520-27-4

Description :

Overview of Diosmin

Diosmin is a semisynthetic flavonoid-based glycoside which is utilised to treat chronic venous insufficiency or haemorrhoids, as well as lymphedema. It is renowned for its venotonic and vasculoprotective qualities. Diosmin is widely used in the field of vascular medicine to improve the venous tone, decrease capillary permeability, and enhance lymphatic drainage.

This API appears as a pale yellow to yellow powder with limited water solubility but good stability. Its mechanism—enhancement of venous tone, reduction of capillary permeability, improvement of lymphatic drainage, and anti-inflammatory effects—provides comprehensive treatment for venous and lymphatic disorders.

Related products include Hesperidin, Troxerutin, Calcium Dobesilate, and other venotonic and vasculoprotective agents used in vascular disease management. It is often combined with Ibuprofen in formulations for enhanced anti-inflammatory effects.

Applications of Diosmin

Pharmaceutical API

• Used in venotonic and vasculoprotective medications
• Effective in treating chronic venous insufficiency (CVI)
• Used for haemorrhoid treatment (acute and chronic)
• Applied in lymphedema and venous leg ulcer management
• Reduces symptoms of varicose veins

Formulation Development

• Used in tablets and film-coated tablets (often micronised for better absorption)
• Frequently combined with Hesperidin in a 90:10 ratio (micronised purified flavonoid fraction - MPFF)
• May be combined with NSAIDs like Ibuprofen for synergistic effects
• Offers good stability in solid dosage forms
• Micronisation improves bioavailability

Vascular & Lymphatic Treatment

• Improves venous tone and reduces venous distensibility
• Reduces symptoms of leg heaviness, pain, and swelling
• Decreases capillary fragility and permeability
• Enhances lymphatic drainage
• Provides anti-inflammatory and antioxidant effects

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Store in a cool, dry place away from light and moisture
• Follow COA and MSDS instructions strictly

Where to Buy Diosmin?

Diosmin Manufacturer

ChemicalBull supplies high-purity Diosmin API, meeting IP/EP/USP quality standards for pharmaceutical formulations.

Diosmin Supplier & Distributor

• Available in bulk packing for formulation units
• Available in micronised and non-micronised grades
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Diosmin medicine?
   

   Diosmin is a flavonoid-based venotonic medication used to treat venous circulation disorders, haemorrhoids, and lymphatic insufficiency.
   
   

2. What is Diosmin's structure?
   

   Diosmin is a flavone glycoside with the molecular formula C₂₈H₃₂O₁₅, consisting of diosmetin (aglycone) attached to a rutinose sugar moiety.
   
   

3. What is Diosmin used for?
   

   It is used for treating chronic venous insufficiency, haemorrhoids, varicose veins, leg ulcers, and lymphedema by improving venous tone and reducing inflammation.