Bosentan
Grade
Monohydrate
Cas No :
157212-55-0
Form :
Solid
Molecular Weight :
569.6
Molecular Formula :
C27H29N5O6S · H2O
Melting Point :
107-109°C
Solubility :
Methanol
Description :
Bosentan is a white to off-white crystal powder used extensively in the health and pharmaceutical sectors to act as an effective endothelin antagonist. A key feature of bosentan's structure is its dual antagonistic activity on endothelin-A and endothelin-B receptors, which helps relax blood vessels, reduce pulmonary vascular resistance, and improve oxygen transport. Complementary pharmaceutical compounds such as Disodium Succinate and Ethyl Oleate are often used alongside Bosentan to enhance formulation stability and therapeutic efficacy. It is available in bulk and pharmaceutical-grade packaging — contact us to get the best price for your order.
Bosentan is widely used as an active pharmaceutical ingredient (API) in the treatment of pulmonary arterial hypertension (PAH). It reduces pulmonary vascular resistance, improves exercise tolerance, and delays disease progression.
It's utilised in treating conditions that are associated with constriction of the arteries, as well as endothelial dysfunction, as well as PAH, causing systemic sclerosis and chronic thromboembolic pulmonary hypertension.
Bosentan is often used alongside other medications such as phosphodiesterase inhibitors or prostacyclin analogues to enhance clinical outcomes in severe pulmonary hypertension cases.
In R&D, Bosentan is used to study endothelin signalling pathways, vascular biology, and receptor antagonism mechanisms, as well as in the development of new cardiovascular drugs.
Always wear protective gloves, goggles, and lab coats when handling Bosentan.
Avoid inhalation of dust and direct contact with skin or eyes.
Handle in a well-ventilated area or under a chemical fume hood.
Store in tightly sealed containers in a cool, dry place away from heat, moisture, and direct sunlight.
Dispose of unused material according to local pharmaceutical and environmental safety regulations.
ChemicalBull manufactures and supplies high-quality Bosentan suitable for pharmaceutical and clinical applications. Each batch is rigorously tested for purity, potency, and compliance with global regulatory standards.
Available in bulk and pharmaceutical-grade packaging, Bosentan is delivered securely with reliable logistics, regulatory support, and technical assistance across Vapi and globally.
Supplied in moisture-resistant, sealed containers with flexible order quantities. ChemicalBull ensures consistent quality, reliable supply, and competitive pricing for large-scale pharmaceutical manufacturers and R&D labs. Explore more Pharmaceutical Intermediates and Fine Chemicals to support your formulation and research requirements.
For detailed information on safety, storage, handling, and toxicity, request the official Material Safety Data Sheet (MSDS) for Bosentan from ChemicalBull.
