4-Toluenesulfonyl Isocyanate | 4083-64-1

Cas No :

4083-64-1

Form :

Solid 

Molecular Weight :

197.2 G/Mol

Molecular Formula :

C8H7NO3S

Boiling Point :

200 °C

Melting Point :

85 °C

Flash Point :

105 °C

Solubility :

Soluble In Acetone, Ethyl Acetate, And Dichloromethane; Insoluble In Water

Description :

Overview of 4-Toluenesulfonyl Isocyanate

4-Toluenesulfonyl Isocyanate is a highly reactive sulfonyl isocyanate compound widely used as an industrial intermediate in organic synthesis, agrochemical manufacturing, and pharmaceutical production. It contains both an isocyanate functional group (-NCO) and a sulfonyl group, making it valuable in multi-step chemical reactions.

As an industrial chemical, 4-Toluenesulfonyl Isocyanate is used in controlled manufacturing environments where high reactivity and selective functional group transformation are required.


Applications of 4-Toluenesulfonyl Isocyanate

Pharmaceutical & API Intermediates

4-Toluenesulfonyl Isocyanate is used as a reactive intermediate in the synthesis of pharmaceutical compounds. It facilitates carbamate and urea formation during drug development processes.

It may be used alongside Triphenylphosphine Oxide, Tetrabutylammonium Hydrogen Sulfate, and Diethyl Sulfate in regulated organic synthesis systems.

Agrochemical Manufacturing

The compound plays a role in producing herbicide and pesticide intermediates, where isocyanate chemistry supports functional group modification.

Specialty Chemical Synthesis

4-Toluenesulfonyl Isocyanate is utilized in preparing sulfonamide derivatives and specialty polymer additives in industrial-scale production.

Research & Laboratory Reagents

It is also employed in research laboratories for advanced organic synthesis, particularly in reactions requiring sulfonyl isocyanate functionality.


Safety & Handling Guidelines

  • Store in tightly sealed containers under dry, cool conditions

  • Protect from moisture, as isocyanates react with water

  • Avoid inhalation of vapors

  • Prevent skin and eye contact

  • Use appropriate PPE including gloves, goggles, and protective clothing

  • Handle under controlled industrial conditions with proper ventilation

Always consult the MSDS before handling.


Where to Buy 4-Toluenesulfonyl Isocyanate?

4-Toluenesulfonyl Isocyanate Manufacturer

4-Toluenesulfonyl Isocyanate is manufactured under strict industrial quality standards to ensure high purity and consistent reactivity.

4-Toluenesulfonyl Isocyanate Supplier & Distributor

Buy 4-Toluenesulfonyl Isocyanate from Chemicalbull Pvt. Ltd., a trusted industrial chemicals supplier and distributor in India, offering reliable sourcing and compliant logistics support.

For bulk supply and pricing details, contact Chemicalbull Pvt. Ltd. for a competitive industrial quotation.


MSDS for 4-Toluenesulfonyl Isocyanate

The MSDS for 4-Toluenesulfonyl Isocyanate provides detailed information regarding hazard identification, handling precautions, storage requirements, exposure controls, and emergency response measures.


Frequently Asked Questions (FAQs)

  1. What is the formula of 4-Toluenesulfonyl Isocyanate?

    The chemical formula of 4-Toluenesulfonyl Isocyanate is C₈H₇NO₃S.

  2. What is the structure of 4-Toluenesulfonyl Isocyanate?

    Its structure consists of a para-methyl substituted benzene ring attached to a sulfonyl group (-SO₂-) and an isocyanate group (-NCO).

  3. What is 4-Toluenesulfonyl Isocyanate used for?

    It is used in pharmaceutical intermediates, agrochemical synthesis, and specialty organic reactions.

  4. How is 4-Toluenesulfonyl Isocyanate synthesized?

    It is typically synthesized through controlled reaction processes involving sulfonyl chloride derivatives and isocyanate-forming reagents under regulated industrial conditions.

  5. Is 4-Toluenesulfonyl Isocyanate hazardous?

    Yes, it is a reactive compound and must be handled under strict industrial safety protocols as outlined in the MSDS.