Trimethylsilyl Trifluoromethanesulfonate
Description :
Overview of Trimethylsilyl Trifluoromethanesulfonate
Trimethylsilyl Trifluoromethanesulfonate (TMSOTf) is a powerful silylating agent and Lewis acid catalyst used extensively in organic synthesis and pharmaceutical manufacturing. Known for its exceptional reactivity in protecting alcohols, activating carbonyls, and catalyzing various transformations, TMSOTf is widely used in pharmaceutical synthesis, carbohydrate chemistry, and advanced organic synthesis.
This compound appears as a colorless liquid that fumes in moist air. Its combination of trimethylsilyl and triflate groups provides unique reactivity as both a silylating agent and a strong Lewis acid catalyst.
Related products include Triethylchlorosilane, Trimethylsilyl Chloride, Trifluoromethanesulfonic Acid, and other silylating agents used in pharmaceutical synthesis.
Applications of Trimethylsilyl Trifluoromethanesulfonate
Pharmaceutical Synthesis
- Used in protecting alcohol functional groups (TMS protection)
- Applied as a Lewis acid catalyst in glycosylation reactions
- Used in carbohydrate synthesis and oligosaccharide preparation
Industrial Organic Synthesis
- Used as a powerful silylating reagent
- Applied in preparing trimethylsilyl ethers and esters
- Used in dehydration and condensation reactions
Advanced Chemical Transformations
- Used in biomolecule protection and modification
- Applied in stereoselective synthesis
- Used in asymmetric synthesis programs
- Applied in developing new catalytic systems
Safety & Handling Guidelines
- HIGHLY REACTIVE and CORROSIVE—handle with extreme caution
- MOISTURE SENSITIVE—reacts violently with water
- Releases toxic fumes (HF, SO₂) upon hydrolysis
- Use only in strictly anhydrous conditions under an inert atmosphere
- Handle in a well-ventilated fume hood with proper containment
- Wear full PPE, including acid-resistant gloves, face shield
Where to Buy Trimethylsilyl Trifluoromethanesulfonate?
Trimethylsilyl Trifluoromethanesulfonate Manufacturer
ChemicalBull supplies high-purity Trimethylsilyl Trifluoromethanesulf
TMSOTf | Trimethylsilyl Trifluoromethanesulfonate
onate for pharmaceutical and research applications.
Trimethylsilyl Trifluoromethanesulfonate Supplier & Distributor
- It is available in controlled quantities for use in pharmaceuticals.
- Anhydrous grade with high purity (>=98 percent, greater than 99 percent)
- Specially designed moisture-resistant packaging with inert gas
- COA MSDS as well as a full safety information are provided
MSDS
Complete reactivity warnings along with information about corrosivity, as well as emergencies procedures.
Frequently Asked Questions (FAQs)
-
What is Trimethylsilyl Trifluoromethanesulfonate used for?
Used as a silylating agent for alcohol protection, a Lewis acid catalyst for glycosylation and other reactions, and in pharmaceutical synthesis. -
What is the molecular formula?
Molecular formula: C₄H₉F₃O₃SSi with molecular weight 222.26 g/mol. -
Why is TMSOTf such a powerful reagent?
Triflate is an excellent leaving group; strong Lewis acidity; high silylating power; activates carbonyl compounds effectively.
