Tert-Butyl Isocyanate | 1609-86-5

Description :

Overview of Tert-Butyl Isocyanate

Tert-Butyl Isocyanate is a reactive isocyanate compound used in pharmaceutical synthesis, polymer chemistry, and as a derivatizing agent in analytical chemistry. Known for its bulky tert-butyl group providing steric effects, high reactivity with nucleophiles, and use in protecting group chemistry, Tert-Butyl Isocyanate is widely used in pharmaceutical manufacturing, producing carbamates, and specialty chemical synthesis.

This compound appears as a colorless liquid with a characteristic pungent odor. Its isocyanate functionality, combined with the bulky tert-butyl group, provides unique reactivity patterns.

Related products include Phenyl Isocyanate, Methyl Isocyanate, and other isocyanates used in pharmaceutical synthesis and polymer chemistry.

Applications of Tert-Butyl Isocyanate

Pharmaceutical Synthesis

• It is used to introduce tert-butyl carbamate (Boc) to protect certain groups
• Utilized for pharmaceutical intermediate synthesis
• It is used in the preparation of drugs for drug testing
• Used in the synthesis of peptides as well as protection

Analytical Chemistry

• It is used as a desivatizing agent for the GC-MS analysis
• Utilized for amino acid analysis
• Used in preparing volatile derivatives
• Used in the creation of analytic methods

Industrial Chemical Synthesis

• Used in producing specialty chemicals
• Applied in synthesizing polymer additives
• Used in manufacturing agrochemical intermediates
• Applied in developing performance chemicals

Safety & Handling Guidelines

• HIGHLY TOXIC—fatal if inhaled
• FLAMMABLE LIQUID—keep away from ignition sources
• MOISTURE SENSITIVE—reacts with water, releasing CO₂
• Use only in a well-ventilated fume hood
• Wear appropriate PPE, including a respirator, gloves, and a face shield
• Handle under anhydrous conditions
• Store in tightly sealed containers under inert gas

Where to Buy Tert-Butyl Isocyanate?

Tert-Butyl Isocyanate Manufacturer

ChemicalBull supplies high-purity Tert-Butyl Isocyanate for pharmaceutical and research applications.

Tert-Butyl Isocyanate Supplier & Distributor

• Available in controlled quantities for authorized use
• High-purity anhydrous grade (98%, 99%)
• Special moisture-resistant packaging under inert gas
• COA, MSDS, and comprehensive safety documentation provided

MSDS

Includes comprehensive toxicity warnings, reactivity information, and emergency procedures.

Frequently Asked Questions (FAQs)

1. What is Tert-Butyl Isocyanate used for?
   

   Used in introducing Boc protecting groups, pharmaceutical synthesis, GC-MS derivatization, and producing carbamates.
   
   

2. What is the molecular formula?
   

   Molecular formula: C₅H₉NO with molecular weight 99.13 g/mol.
   
   

3. What is the structure?
   

   Isocyanate group attached to tert-butyl: (CH₃)₃C-N=C=O.