Tert-butyl Isocyanate | 1609-86-5

Description :

Overview of Tert-Butyl Isocyanate

Tert-Butyl Isocyanate is a reactive isocyanate compound used in pharmaceutical synthesis, polymer chemistry, and as a derivatizing agent in analytical chemistry. Known for its bulky tert-butyl group providing steric effects, high reactivity with nucleophiles, and use in protecting group chemistry, Tert-Butyl Isocyanate is widely used in pharmaceutical manufacturing, producing carbamates, and specialty chemical synthesis.

This compound appears as a colorless liquid with a characteristic pungent odor. Its isocyanate functionality, combined with the bulky tert-butyl group, provides unique reactivity patterns.

Related products include Phenyl Isocyanate, Methyl Isocyanate, and other isocyanates used in pharmaceutical synthesis and polymer chemistry.

Applications of Tert-Butyl Isocyanate

Pharmaceutical Synthesis

• It is used to introduce tert-butyl carbamate (Boc) to protect certain groups
• Utilized for pharmaceutical intermediate synthesis
• It is used in the preparation of drugs for drug testing
• Used in the synthesis of peptides as well as protection

Analytical Chemistry

• It is used as a desivatizing agent for the GC-MS analysis
• Utilized for amino acid analysis
• Used in preparing volatile derivatives
• Used in the creation of analytic methods

Industrial Chemical Synthesis

• Used in producing specialty chemicals
• Applied in synthesizing polymer additives
• Used in manufacturing agrochemical intermediates
• Applied in developing performance chemicals

Safety & Handling Guidelines

• HIGHLY TOXIC—fatal if inhaled
• FLAMMABLE LIQUID—keep away from ignition sources
• MOISTURE SENSITIVE—reacts with water, releasing CO₂
• Use only in a well-ventilated fume hood
• Wear appropriate PPE, including a respirator, gloves, and a face shield
• Handle under anhydrous conditions
• Store in tightly sealed containers under inert gas

Where to Buy Tert-Butyl Isocyanate?

Tert-Butyl Isocyanate Manufacturer

ChemicalBull supplies high-purity Tert-Butyl Isocyanate for pharmaceutical and research applications.

Tert-Butyl Isocyanate Supplier & Distributor

• Available in controlled quantities for authorized use
• High-purity anhydrous grade (98%, 99%)
• Special moisture-resistant packaging under inert gas
• COA, MSDS, and comprehensive safety documentation provided

MSDS

Includes comprehensive toxicity warnings, reactivity information, and emergency procedures.

Frequently Asked Questions (FAQs)

1. What is Tert-Butyl Isocyanate used for?
   

   Used in introducing Boc protecting groups, pharmaceutical synthesis, GC-MS derivatization, and producing carbamates.
   
   

2. What is the molecular formula?
   

   Molecular formula: C₅H₉NO with molecular weight 99.13 g/mol.
   
   

3. What is the structure?
   

   Isocyanate group attached to tert-butyl: (CH₃)₃C-N=C=O.

ChemicalBull supplies Tert-butyl Isocyanate across India, serving customers in Andhra Pradesh, Arunachal Pradesh, Assam, Bihar, Chhattisgarh, Goa, Gujarat, Haryana, Himachal Pradesh, Jharkhand, Karnataka, Kerala, Madhya Pradesh, Maharashtra, Manipur, Meghalaya, Mizoram, Nagaland, Odisha, Punjab, Rajasthan, Sikkim, Tamil Nadu, Telangana, Tripura, Uttar Pradesh, Uttarakhand, and West Bengal, as well as the Union Territories of Andaman & Nicobar Islands, Chandigarh, Dadra & Nagar Haveli and Daman & Diu, Delhi, Jammu & Kashmir, Ladakh, Lakshadweep, and Puducherry. We serve pharmaceutical, chemical, research, academic, laboratory, manufacturing, and industrial customers with reliable nationwide delivery.