Sodium Cyanoborohydride
Description :
Overview of Sodium Cyanoborohydride
Sodium Cyanoborohydride is a mild and selective reducing agent used extensively in organic synthesis, pharmaceutical manufacturing, and biochemistry. Known for its ability to selectively reduce imines and iminium ions at neutral to mildly acidic pH, while leaving most carbonyl groups unreacted, Sodium Cyanoborohydride is widely used in reductive amination, pharmaceutical synthesis, and the preparation of amine derivatives.
This compound appears as a white to off-white crystalline powder. Its cyano-substituted borohydride structure provides unique selectivity and stability compared to sodium borohydride, making it invaluable for specific transformations.
Related products include Sodium Borohydride, Sodium Triacetoxyborohydride, and other reducing agents used in organic synthesis. May be used in reactions involving Diethyl Oxalate and other carbonyl compounds requiring selective reduction.
Applications of Sodium Cyanoborohydride
Pharmaceutical Synthesis
- Used in reductive amination reactions
- Applied in synthesizing secondary and tertiary amines
- Used in preparing pharmaceutical intermediates
- Applied in manufacturing active pharmaceutical ingredients
Organic Synthesis
- Used in the selective reduction of imines
- Applied in the reductive alkylation of amines
- Used in the Borch reaction
- Applied in reducing iminium ions
Biochemistry & Research
- Used in protein modification studies
- Applied in glycoprotein conjugation
- Used in labeling biomolecules
- Applied in bioconjugation chemistry
- Used in preparing affinity reagents
- Applied in chemical biology research
Safety and Guidelines for Handling
- toxin and releases harmful hydrocyanide in the event of acidification
- Do not inhale the dust and avoid contact with acidic substances
- Make sure you wear gloves, goggles, and suitable clothes
- Handle inside a ventilated fume hood
- Store in tightly shut containers and store in a cool, dry area
- Stay clear of the oxidizing agents, acids, and water
- To dispose of, according to dangerous cyanide waste pro colls
- Utilize a cyanide antidote kit in your working area
- Be sure to follow COA and MSDS guidelines completely
Where to Buy Sodium Cyanoborohydride?
Sodium Cyanoborohydride Manufacturer
ChemicalBull supplies high-purity Sodium Cyanoborohydride for pharmaceutical and research applications.
Sodium Cyanoborohydride Supplier & Distributor
- It is available in large quantities for drug use.
- Grades with high purity (95 percent, 98%)
- Appropriate safety packaging
- COA MSDS as well as full security documentation are included.
MSDS
includes comprehensive warnings about toxicity as well as cyanide-related hazard information and strict handling guidelines.
Frequently Asked Questions (FAQs)
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What is Sodium Cyanoborohydride used for?
Used primarily in reductive amination to form C-N bonds, selective reduction of imines, pharmaceutical synthesis, and bioconjugation chemistry. -
What is the molecular formula?
Molecular formula: NaBH₃CN with molecular weight 62.84 g/mol. -
Why is it selective for imines over ketones?
The electron-withdrawing cyano group reduces hydride-donating ability; reacts preferentially with more electrophilic iminium ions at pH 6-8; most ketones are unreactive.
