Reserpine | 50-55-5

Description :

Overview of Reserpine

Reserpine is an indole alkaloid derived from Rauwolfia serpentina used as an antihypertensive and antipsychotic agent. Known for its mechanism of depleting catecholamine and serotonin stores in neurons, Reserpine is used in treating hypertension, psychotic disorders, and certain movement disorders. However, its use has declined as newer agents have become available.

This API appears as a white to pale buff, or slightly yellowish, crystalline powder, with light sensitivity and limited water solubility. Its mechanism—irreversible inhibition of vesicular monoamine transporter (VMAT)—depletes neurotransmitter stores, leading to reduced sympathetic activity and antipsychotic effects.

Related products include Methyldopa, Clonidine, Chlorpromazine, and other centrally-acting antihypertensives and antipsychotic medications.

Applications of Reserpine

Pharmaceutical API

• It is used in antihypertensive drugs (often when combined with other medications)
• Used to treat anxiety and psychotic disorders.
• Utilized to treat tardive dyskinesia as well as other disorders of movement
• Historical use in schizophrenia treatment
• Used in veterinary medicine in order to provide sedation for animals

Formulation Development

• Utilized as a tablet (immediate-release forms)
• Most often, it is mixed with vasodilators or diuretics (e.g., with furosemide )
• The formulations with low-dose amounts are quite common (0.1-0.25 mg)
• requires protection against water and light
• Stable in correctly formulated dose forms that are solid
• Light-sensitive--amber packaging required

Cardiovascular & Psychiatric Treatment

• Provides sustained blood pressure reduction
• Long duration of action (effects last days to weeks)
• Depletes peripheral and central catecholamines
• Used when other antihypertensives are contraindicated or ineffective
• Requires careful monitoring for depression and side effects

Safety & Handling Guidelines

• Potent drug—avoid inhalation of powder
• Use gloves, goggles, and protective clothing during handling
• Protect from light exposure
• Store in a cool, dry place in light-resistant containers
• Follow COA and MSDS instructions strictly

Where to Buy Reserpine?

Reserpine Manufacturer

ChemicalBull supplies high-purity Reserpine API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Reserpine Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• Requires controlled storage conditions
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What are the uses of Reserpine?
   

   Reserpine is used for treating hypertension (especially in combination products), psychotic disorders, agitation, and certain movement disorders; it is also used in research as a tool for studying monoamine systems.
   
   

2. What is the structure of Reserpine?
   

   Reserpine is an indole alkaloid with molecular formula C₃₃H₄₀N₂O₉, containing multiple ring systems including indole and quinoline moieties with methoxy and ester functional groups.
   
   

3. How does Reserpine work?
   

   It irreversibly inhibits VMAT (vesicular monoamine transporter), preventing storage of catecholamines and serotonin in vesicles, leading to neurotransmitter depletion and reduced sympathetic activity.