Pyrimethamine | 58-14-0

Description :

Overview of Pyrimethamine

Pyrimethamine is a pharmaceutical active ingredient primarily used as an antiprotozoal and antiparasitic agent. It works by inhibiting dihydrofolate reductase in protozoa, thereby preventing DNA synthesis and cell replication. Pyrimethamine is widely used in the treatment and prevention of diseases such as toxoplasmosis and malaria, often in combination with other therapeutic agents.

Pyrimethamine appears as a white to off-white crystalline powder with good chemical stability. It is practically insoluble in water but soluble in organic solvents, making it suitable for oral solid dosage forms such as tablets. Due to its targeted mechanism of action and established clinical use, it remains an important API in infectious disease management.

ChemicalBull supplies pharma-grade Pyrimethamine with high purity, consistent particle size, and reliable batch-to-batch quality suitable for regulated pharmaceutical manufacturing. Each shipment is supported with complete documentation, including MSDS, COA, and technical data sheets, ensuring compliance with pharmaceutical quality standards.

As a trusted chemical supplier and reliable distributor, ChemicalBull ensures dependable availability of Pyrimethamine for pharmaceutical manufacturers. You may also like Sulfadoxine, Trimethoprim, Proguanil Hydrochloride, and Pharmaceutical APIs for related antiprotozoal and anti-infective applications.

Applications of Pyrimethamine

Pharmaceutical Formulations

• Used in oral tablet formulations

• Applied in combination therapies for protozoal infections

• Suitable for regulated solid dosage forms
  
  

Infectious Disease & Clinical Use

• Used in the treatment of toxoplasmosis

• Applied in malaria prevention and therapy

• Prescribed in parasitic infection management
  
  

Generic Drug Manufacturing

• Used in branded and generic antiparasitic medicines

• Suitable for large-scale pharmaceutical production

• Ensures consistent potency and formulation stability
  
  

Pharmaceutical Research & Development

• Used in antiprotozoal drug research

• Applied in bioequivalence and stability studies

• Suitable for controlled pharmaceutical laboratories
  
  

Safety & Handling Guidelines

• Handle using gloves and appropriate protective equipment

• Avoid inhalation of fine powder

• Use in well-ventilated pharmaceutical manufacturing areas

• Store in tightly sealed containers away from moisture and light

• Follow MSDS and standard pharmaceutical safety practices
  
  

Where to Buy Pyrimethamine?

Pyrimethamine Manufacturer

ChemicalBull supplies pharmaceutical-grade Pyrimethamine suitable for antiparasitic and anti-infective drug formulations.

Pyrimethamine Supplier & Distributor

• Bulk and customised pharmaceutical packaging options

• Export-grade quality with COA, TDS & MSDS

• Reliable supply across India and international markets

• Trusted chemical supplier for pharmaceutical APIs
  
  

Pyrimethamine MSDS

The Pyrimethamine MSDS provides essential information on safe handling, storage conditions, exposure controls, stability, and emergency procedures. Always review the MSDS before bulk handling or pharmaceutical manufacturing use.

Frequently Asked Questions (FAQs)

1. Is Pyrimethamine commonly used alone or in combination therapy?

   It is most often used in combination with other agents to enhance therapeutic effectiveness and reduce resistance.
   
   

2. What type of infections is Pyrimethamine mainly prescribed for?

   It is primarily prescribed for protozoal infections such as toxoplasmosis and certain forms of malaria.
   
   

3. Is Pyrimethamine water-soluble?

   No, it is practically insoluble in water, which is why it is mainly formulated into tablets.
   
   

4. Does Pyrimethamine affect folate metabolism?

   Yes, it inhibits folate synthesis in protozoa by blocking dihydrofolate reductase.
   
   

5. Is safety documentation provided with the supply?

   Yes, every shipment includes MSDS, COA, and complete technical documentation.