Poloxamer 188
Form :
Powder
Molecular Weight :
8400 G/Mol
Boiling Point :
250 °C
Solubility :
Soluble In Water
Flash Point :
200 °C
Description :
Overview of Poloxamer 188
Poloxamer 188 is a non-ionic triblock copolymer surfactant composed of polyethene oxide and polypropylene oxide segments. It is widely used in pharmaceutical, cosmetic, personal care, and biotechnology formulations due to its excellent emulsifying, solubilising, stabilising, and dispersing properties. Poloxamer 188 is known for its high biocompatibility, low toxicity, and mild nature, making it suitable for sensitive and regulated applications.
Its CAS number is 9003-11-6, and it is typically supplied as a white to off-white free-flowing powder or flakes. Poloxamer 188 is highly water-soluble and stable across a wide pH range. It is often used in combination with other excipients, surfactants, and stabilisers such as Poloxamer 407, PEG derivatives, polysorbates, and emulsifiers to enhance formulation performance in aqueous and injectable systems.
Application of Poloxamer 188
Pharmaceutical Applications
Poloxamer 188 is extensively used in injectable formulations, drug delivery systems, vaccines, ophthalmic solutions, and oral liquids. It acts as a solubiliser and stabiliser for poorly soluble drugs and helps protect cells and proteins from shear stress and aggregation.
Cosmetic and Personal Care Products
In cosmetics, Poloxamer 188 is used in cleansers, micellar waters, makeup removers, creams, lotions, and serums. It improves solubility, clarity, and mild cleansing while remaining gentle on skin and eyes.
Biotechnology and Cell Culture
Poloxamer 188 is widely used in cell culture media and bioprocessing to protect cells from mechanical damage and improve cell viability during agitation and aeration.
Industrial and Speciality Applications
It is also used in diagnostic reagents, laboratory formulations, and speciality chemical systems where non-ionic behaviour, stability, and low foaming are required.
Related Products for
Polysorbate 80, PEG-40 Hydrogenated Castor Oil
Safety and Handling Guidelines
- Store in a cool, dry place away from moisture
- Keep containers tightly sealed
- Avoid inhalation of fine powder during handling
- Use protective gloves and masks when handling bulk quantities
- Follow formulation guidelines as per regulatory standards
When used as recommended, Poloxamer 188 is safe, stable, and well-tolerated in pharmaceutical and cosmetic applications.
Where to Buy Poloxamer 188?
Poloxamer 188 Manufacturer
Manufactured by approved pharmaceutical and speciality chemical producers under strict quality control to ensure high purity, consistent molecular weight, and regulatory compliance.
Poloxamer 188 Supplier & Distributor
Triveni Chemicals supplies Poloxamer 188 for pharmaceutical, cosmetic, and biotech applications. As a trusted supplier, distributor, trader, and exporter, we ensure consistent quality, reliable supply, and complete technical documentation.
Poloxamer 188 MSDS
The MSDS provides detailed information on safe handling, storage, hazards, and compliance requirements and is available on request.
Frequently Asked Questions (FAQs)
What is Poloxamer 188 used for?
It is used as a solubiliser, emulsifier, and stabiliser in pharmaceuticals, cosmetics, and biotechnology formulations.Is Poloxamer 188 safe for pharmaceutical use?
Yes, it is pharmaceutically accepted and widely used in injectable and oral formulations.Is Poloxamer 188 water-soluble?
Yes, it is highly soluble in water and suitable for clear aqueous systems.What is the difference between Poloxamer 188 and Poloxamer 407?
Poloxamer 188 has a lower molecular weight and viscosity, while Poloxamer 407 forms thermoreversible gels and is used for controlled release systems.Can Poloxamer 188 be used in sensitive skin products?
Yes, due to its mild and non-irritating nature, it is suitable for sensitive skin and ophthalmic products.
