Nonivamide
Description :
Overview of Nonivamide
Nonivamide (Pelargonic Acid Vanillylamide, PAVA) is an artificial capsaicinoid that is used as a key ingredient in topical analgesics, sprays for self-defense, and pharmaceutical formulations. It is renowned for its powerful TRPV1 receptor stimulation, which results in the same analgesic and warming effects as capsaicin, but with better reliability and stability. The nonivamide ingredient is extensively used for pain relief in product formulations and pepper spray formulations, as well as research in the field of pharmaceuticals.
This substance appears as a white or off-white crystal powder that has distinctive pungent characteristics. Its vanillylamide form with the nonanoyl (pelargonic acid) side chain is a powerful capsaicinoid action with increased quality and stability when compared with natural capsaicin.
Similar products include Capsaicin Oleoresin, Pelargonic Acid, and other TRPV1 agonists utilized for self-defense and pharmaceutical applications.
Applications of Nonivamide
Pharmaceutical & Medical
- Utilized in the formulation of topical analgesics used for pain relief.
- In creams, patches, and ointments to treat muscle pain
- It is used to treat the neuropathic pain syndromes
- Used for the treatment of arthritis pain
- Utilized as a pain reliever for sports medicine products
- Used for the treatment of neuropathy in diabetics.
- Utilized to treat chronic pain disorders
- Used in counterirritants or rubefacient forms
Self-Defense & Security
- It is used as an active ingredient for pepper spray.
- It is used in aerosols for personal defense
- Utilized as a riot control agent
- It is used in law enforcement, security, and other applications
- It is used in animal repellent sprays
- Used in ammunition for training (marking round)
Research & Development
- Utilized for TRPV1 receptor studies
- Applied in pain mechanism studies
- It is used in the development of new analgesic substances
- It is used to study the sensory neurobiology
- Utilized in research on pharmacology
- Applied in developing drug delivery systems
Safety & Handling Guidelines
- Extremely potent irritant—avoid inhalation and skin contact
- Use gloves, goggles, a face shield, and protective clothing
- Handle in a well-ventilated fume hood
- Avoid creating aerosols or dust
- Store in tightly closed containers in a cool, dry place
- Keep away from eyes, mucous membranes, and broken skin
- Have an emergency eyewash and shower available
- Follow COA and MSDS instructions strictly
Where to Buy Nonivamide?
Nonivamide Manufacturer
ChemicalBull supplies high-purity Nonivamide that meets pharmaceutical and industrial quality standards for authorized applications.
Nonivamide Supplier & Distributor
- Available in controlled quantities for pharmaceutical and authorized use
- High-purity grades (97%, 98%, 99%)
- Pharmaceutical and technical grades
- COA, MSDS, and regulatory documentation provided
MSDS
Includes comprehensive safety instructions, exposure controls, first aid measures, and handling protocols.
Frequently Asked Questions (FAQs)
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What is Nonivamide used for?
Used in topical analgesics for pain relief, pepper spray and self-defense products, research on pain mechanisms, and pharmaceutical development. -
What is Nonivamide synthesis?
Synthesized by acylation of vanillylamine with nonanoyl chloride (pelargonic acid chloride) or through direct coupling of vanillylamine with pelargonic acid. -
What is Nonivamide CAS No?
CAS number: 2444-46-4.
