Leflunomide | 75706-12-6

Description :

Overview of Leflunomide

Leflunomide is a disease-modifying antirheumatic drug (DMARD) used for treating rheumatoid arthritis and psoriatic arthritis. Known for its immunomodulatory and anti-inflammatory properties, Leflunomide is widely used in the management of chronic inflammatory joint disease.

This API appears as a white to almost white powder and is stable under controlled storage conditions. Its mechanism—inhibition of dihydroorotate dehydrogenase and pyrimidine synthesis—suppresses lymphocyte proliferation and reduces inflammatory response in autoimmune conditions.

Related products include Methotrexate, Sulfasalazine, Hydroxychloroquine, and other DMARDs used to treat rheumatological and autoimmune diseases.

Applications of Leflunomide

Pharmaceutical API

• Used in disease-modifying antirheumatic medications
• Effective in treating active rheumatoid arthritis and psoriatic arthritis
• Inhibits pyrimidine synthesis and lymphocyte proliferation
• Reduces joint damage progression and improves physical function

Formulation Development

• Used in film-coated tablets
• Suitable for once-daily dosing
• Offers good bioavailability and long half-life
• Stable in solid dosage forms

Rheumatological Treatment

• Helps reduce pain, swelling, and joint stiffness
• Slows structural joint damage in rheumatoid arthritis
• Improves the quality of life in chronic inflammatory arthritis
• Can be used as monotherapy or in combination with other DMARDs

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Teratogenic—handle with extreme caution and follow safety protocols
• Store in a cool, dry place away from light and moisture
• Follow COA and MSDS instructions strictly

Where to Buy Leflunomide?

Leflunomide Manufacturer

ChemicalBull supplies high-purity Leflunomide API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Leflunomide Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Leflunomide used for?
   

   It is used for treating rheumatoid arthritis and psoriatic arthritis to reduce inflammation and slow disease progression.
   
   

2. Is Leflunomide safe during pregnancy?
   

   No, Leflunomide is highly teratogenic and contraindicated in pregnancy. Strict contraceptive measures are required during treatment.
   
   

3. Is Leflunomide stable for tablet formulation?
   

   Yes, it is chemically stable in film-coated tablet formulations.