Hexamethylphosphoramide | 680-31-9

Description :

Overview of Hexamethylphosphoramide

Hexamethylphosphoramide is a highly polar aprotic phosphoramide compound used as a strong coordinating solvent in advanced organic synthesis. It has the Phosphoryl (P=O) group that is bonded to three dimethylamino groups, providing excellent cation-solving capabilities and enhanced reactivity during nucleophilic reactions. Molecular formula: C6H18N3OP, and it is completely miscible with water as well as most organic solvents. Because of its powerful ability to dissolve, it is extensively used in industrial and laboratory chemical processes that require controlled reactions.

Applications of Hexamethylphosphoramide

Organic Synthesis & Reaction Medium

Hexamethylphosphoramide is widely used as a solvent to enhance nucleophilic substitution and elimination reactions. Its strong ability to solvate metal cations increases reaction efficiency and selectivity in complex organic transformations.

It is often used in reaction systems involving strong bases such as Sodium Hydride and Potassium Tert-Butoxide under controlled conditions.

Pharmaceutical & Fine Chemical Manufacturing

In pharmaceutical intermediate production, this solvent improves yields in multi-step synthesis processes that involve highly reactive intermediates. Its high polarity supports better dissolution of reagents and catalysts.

It may be applied in systems where reagents like Phosphorus Oxychloride are used for functional group transformations.

Polymer & Advanced Material Research

Hexamethylphosphoramide is utilized in polymer chemistry and specialty material development where stabilization of charged intermediates is required. It supports controlled polymerization and advanced material synthesis.

Laboratory & Industrial Research Applications

The compound is frequently used in research laboratories for mechanistic studies, rearrangement reactions, and ionic reaction systems requiring high-polarity solvents.

Safety & Handling Guidelines

• Store in tightly sealed containers in a cool, well-ventilated area
• Avoid inhalation and direct skin contact
• Use chemical-resistant gloves, goggles, and protective clothing
• Handle strictly under a chemical fume hood
• Dispose of material according to hazardous waste regulations

Hexamethylphosphoramide is classified as toxic and potentially carcinogenic; strict safety compliance is required during handling. Always consult the official MSDS before use.

Where to Buy Hexamethylphosphoramide?

Hexamethylphosphoramide Manufacturer

Hexamethylphosphoramide is manufactured under controlled chemical processing conditions to ensure high purity, stable composition, and suitability for research and industrial applications.

Hexamethylphosphoramide Supplier & Distributor

Buy Hexamethylphosphoramide from Chemicalbull Pvt. Ltd., a trusted industrial chemical supplier and distributor in India, offering reliable bulk supply and compliant logistics support.

For the latest pricing and bulk supply details, contact Chemicalbull Pvt. Ltd. for a competitive industrial quotation.

MSDS for Hexamethylphosphoramide

The MSDS for Hexamethylphosphoramide provides detailed information on hazard identification, exposure limits, safe handling procedures, storage requirements, and emergency response measures. Industrial users must review the safety data sheet before use.

Frequently Asked Questions (FAQs)

1. What is Hexamethylphosphoramide used for?
   

   It is mainly used as a highly polar aprotic solvent in advanced organic and pharmaceutical synthesis.
   
   

2. Is Hexamethylphosphoramide hazardous?
   

   Yes, it is considered toxic and requires strict safety precautions during handling.
   
   

3. What is the molecular formula of Hexamethylphosphoramide?
   

   The molecular formula is C₆H₁₈N₃OP.
   
   

4. Is Hexamethylphosphoramide soluble in water?
   

   Yes, it is completely miscible with water and many polar organic solvents.
   
   

5. Is MSDS available for Hexamethylphosphoramide?
   

   Yes, the official MSDS can be obtained from Chemicalbull Pvt. Ltd. upon request.