Heptafluorobutyric Acid | 375-22-4

Description :

Heptafluorobutyric Acid Supplier & Manufacturer in India

ChemicalBull is a reliable Heptafluorobutyric Acid supplier, distributor, and exporter in India for HPLC analysis, LC-MS methods, peptide separation, amino-acid sequencing and fluorochemical synthesis. Buyers comparing Heptafluorobutyric Acid manufacturers and suppliers can contact us for grade, purity, concentration, COA, MSDS/SDS, packing, availability and pricing.

Heptafluorobutyric Acid, commonly known as HFBA or Perfluorobutyric Acid, is a fluorinated carboxylic acid. Its CAS Number is 375-22-4, molecular formula is C4HF7O2, and molecular weight is approximately 214.04 g/mol.

Overview of Heptafluorobutyric Acid

Heptafluorobutyric Acid is a short-chain perfluorinated carboxylic acid containing seven fluorine atoms. It is generally supplied as a clear, colourless liquid or as a prepared aqueous solution for chromatographic applications.

Its strongest commercial demand comes from analytical laboratories using it as an ion-pairing reagent or mobile-phase modifier. It can improve the chromatographic behaviour of basic, ionic and polar compounds in suitable reversed-phase methods.

HFBA is available in different forms, including general reagent grade, high-purity sequencing grade and prepared LC-MS or HPLC solutions. Buyers should clearly state the required grade because these products differ in purity, UV absorbance, concentration and suitability for analytical instruments.

Quick Answer

Heptafluorobutyric Acid is mainly used as an ion-pair reagent in HPLC and LC-MS for separating peptides, proteins, amino compounds and other basic analytes.

It is also used in amino-acid sequencing, fluorochemical synthesis and selected zinc electrodeposition processes. Method suitability must be confirmed because HFBA can affect mass-spectrometry response and may require careful system cleaning.

Applications of Heptafluorobutyric Acid

HPLC Ion-Pair Reagent

The primary application of HFBA is as an ion-pairing reagent in reversed-phase high-performance liquid chromatography.

HFBA can interact with positively charged or basic analytes and change their retention on the chromatographic column. This may improve separation, peak shape and selectivity when analysing compounds that are difficult to retain under ordinary reversed-phase conditions.

The correct concentration depends on the analyte, column, mobile phase, detector and validated analytical method.

Peptide and Protein Analysis

Analytical and pharmaceutical laboratories use Heptafluorobutyric Acid as a mobile-phase modifier for selected peptide and protein separations.

It may improve the retention and resolution of basic peptides compared with weaker ion-pairing additives. It has also been used in the HPLC analysis of histone proteins and underivatised peptides.

Laboratories should evaluate recovery, peak shape, column compatibility and instrument response before adopting HFBA in a routine method.

LC-MS Method Development

Specially controlled HFBA solutions may be used as ion-pair reagents in selected LC-MS methods.

Although HFBA can improve chromatographic retention and selectivity, strong ion-pair reagents may suppress ionisation or remain within the LC-MS system. Analysts should use only the concentration required by the validated method and follow suitable instrument-cleaning procedures.

Buyers should request an LC-MS grade or a solution specifically intended for mass-spectrometry applications when required.

Amino-Acid Sequencing

High-purity HFBA may be used as a sequencing reagent in peptide chemistry and amino-acid analysis.

In this application, reagent purity is important because background impurities can interfere with sensitive analytical results. Buyers should confirm assay, UV absorbance, trace impurities and application suitability.

Sequencing-grade material should not be replaced with a general industrial grade without method validation.

Pharmaceutical Research and Quality Control

Pharmaceutical laboratories use HFBA in selected analytical methods for drug substances, pharmaceutical intermediates, peptides and other basic compounds.

It may support method development, impurity profiling and quality-control analysis where ion-pair chromatography is required. The reagent itself is not an active pharmaceutical ingredient.

The grade should be selected according to detector type, analytical sensitivity and regulatory method requirements.

Fluorochemical Synthesis

Fine and specialty chemical manufacturers may use Heptafluorobutyric Acid as a fluorinated building block or reagent.

Its perfluorinated carbon chain can support the development of specialised fluorinated derivatives, research compounds and functional materials. Process suitability depends on the required reaction and downstream product specification.

Heptafluorobutyric Acid Price and Supply

The Heptafluorobutyric Acid price depends on grade, purity, concentration, analytical controls, quantity, packing and delivery destination.

Buyers searching for HFBA price, Perfluorobutyric Acid price, CAS 375-22-4 supplier, HPLC ion-pair reagent or Heptafluorobutyric Acid LC-MS grade can contact ChemicalBull for current availability.

For an accurate quotation, share:

• Required grade and purity

• Neat acid or prepared solution

• Required solution concentration

• Required quantity and packing

• Delivery destination

A prepared analytical solution and neat high-purity acid should not be compared only by pack price. Buyers should consider concentration, analytical specification and usable quantity.

Heptafluorobutyric Acid Sourcing Support

ChemicalBull supports laboratory and commercial Heptafluorobutyric Acid requirements according to grade availability.

Buyers searching for a Heptafluorobutyric Acid manufacturer in India can contact ChemicalBull for sourcing options based on purity, concentration, analytical specification and quantity.

As a B2B Heptafluorobutyric Acid supplier and distributor, ChemicalBull coordinates available product specifications, COA, MSDS/SDS, suitable packing and delivery terms for India and selected export destinations.

Send your analytical method requirement or approved specification to help us identify the appropriate grade.

MSDS for Heptafluorobutyric Acid

The Heptafluorobutyric Acid MSDS/SDS provides information about corrosivity, personal protection, exposure controls, compatible materials, first aid, transportation and disposal.

The document should correspond to the exact product supplied. Neat HFBA and diluted aqueous HFBA solutions may have different hazard and transport classifications.

Buyers may also request the batch-specific COA and available specification for technical approval.

Match the Right HFBA Grade to Your Method

Need Heptafluorobutyric Acid for HPLC, LC-MS, peptide analysis, sequencing or fluorochemical synthesis?

Send your required grade, concentration, quantity, packing and delivery location to ChemicalBull.

We will review your application and share the most suitable available grade with documentation, lead time and commercial pricing.

Related Products

• Trifluoroacetic Acid

• Perfluorooctanoic Acid
  
  
  

Frequently Asked Questions

1. What is Heptafluorobutyric Acid used for?

   HFBA is mainly used as an ion-pairing reagent and mobile-phase modifier in HPLC and selected LC-MS methods. It is also used in peptide analysis, amino-acid sequencing and fluorochemical synthesis.
   
   

2. What is the CAS number of Heptafluorobutyric Acid?

   The CAS Number of Heptafluorobutyric Acid is 375-22-4. Its molecular formula is C4HF7O2, and its molecular weight is approximately 214.04 g/mol.
   
   

3. Are HFBA and Perfluorobutyric Acid the same?

   Yes. Heptafluorobutyric Acid, HFBA and Perfluorobutyric Acid are commonly used names for the same compound.
   
   

4. Can HFBA be used in LC-MS?

   Specially prepared HFBA solutions can be used in selected LC-MS methods. However, HFBA may suppress ionisation and contaminate the instrument, so concentration and cleaning procedures must be validated.
   
   

5. What information is required for an HFBA quotation?

   Buyers should share the required grade, purity, concentration, application, quantity, packing and delivery destination. This helps distinguish neat acid from HPLC, LC-MS or sequencing-grade products.

ChemicalBull supplies Heptafluorobutyric Acid across India, serving customers in Andhra Pradesh, Arunachal Pradesh, Assam, Bihar, Chhattisgarh, Goa, Gujarat, Haryana, Himachal Pradesh, Jharkhand, Karnataka, Kerala, Madhya Pradesh, Maharashtra, Manipur, Meghalaya, Mizoram, Nagaland, Odisha, Punjab, Rajasthan, Sikkim, Tamil Nadu, Telangana, Tripura, Uttar Pradesh, Uttarakhand, and West Bengal, as well as the Union Territories of Andaman & Nicobar Islands, Chandigarh, Dadra & Nagar Haveli and Daman & Diu, Delhi, Jammu & Kashmir, Ladakh, Lakshadweep, and Puducherry. We serve pharmaceutical, chemical, research, academic, laboratory, manufacturing, and industrial customers with reliable nationwide delivery.