Eszopiclone | 138729-47-2

Description :

Overview of Eszopiclone

Eszopiclone is a non-benzodiazepine hypnotic drug used for the treatment of insomnia that manifests as difficulty sleeping, frequent wake-ups or early morning awakening. The drug is known for its specific effect on the GABA-A receptor subtypes as well as its favourable safety profile. Eszopiclone has been extensively utilised as a sleep medication for longer-term and short-term control of insomnia.

The API manifests as an ethereal white-to-light yellow crystallised powder that has limited solubility in water as well as being light-sensitive. The mechanism it uses, selective modulation of GABA-A receptors (a1, a2, and a3 subunits), enhances GABAergic neurotransmission and promotes sleeping onset, keeping regular sleep and increasing overall sleep quality with only minimal effect on the next day.

Related products include Zolpidem, Zaleplon, Zopiclone, and other non-benzodiazepine hypnotics and benzodiazepine sedatives used in insomnia treatment. It may be used alongside nutritional supplements like L-Glutamine in comprehensive sleep health programs.

Applications of Eszopiclone

Pharmaceutical API

• Used in prescription sleep medications for insomnia treatment
• Effective in reducing sleep latency (time to fall asleep)
• Decreases nocturnal awakenings and increases total sleep time
• Improves sleep quality and daytime functioning
• Approved for long-term use (unlike many other hypnotics)
• Treats both transient and chronic insomnia

Formulation Development

• Used in immediate-release tablets
• Available in multiple strengths (1 mg, 2 mg, 3 mg)
• Requires protection from light during manufacturing and storage
• Film-coated tablets for stability and ease of swallowing
• Once-daily bedtime dosing
• Stable in properly formulated and packaged products

Sleep Medicine Treatment

• Rapid onset of action (approximately 30 minutes)
• Duration of action supports a full night's sleep (7-8 hours)
• Lower abuse potential compared to benzodiazepines
• Minimal rebound insomnia upon discontinuation
• Does not significantly suppress REM sleep
• Well-tolerated with a favourable safety profile for long-term use

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Protect from light exposure—use amber containers
• Store in a cool, dry place away from light and moisture
• Controlled substance—follow regulatory requirements for handling and storage
• Follow COA and MSDS instructions strictly

Where to Buy Eszopiclone?

Eszopiclone Manufacturer

ChemicalBull supplies high-purity Eszopiclone API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Eszopiclone Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• Requires controlled substance handling protocols
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Eszopiclone used for?
   

   Eszopiclone is used for treating insomnia, including difficulty falling asleep, staying asleep, and early morning awakening, in both short-term and chronic cases.
   
   

2. How does Eszopiclone work?
   

   It selectively binds to and modulates GABA-A receptors in the brain, enhancing GABA's inhibitory effects and promoting sedation and sleep.
   
   

3. What is the difference between Eszopiclone and Zopiclone?
   

   Eszopiclone is the S-enantiomer (active form) of racemic Zopiclone, providing similar efficacy with a potentially improved pharmacological profile.