Estradiol Anhydrous | 50-28-2

Description :

Overview of Estradiol Anhydrous

Estradiol Anhydrous is a bioidentical form of the primary female sex hormone estrogen used in hormone replacement therapy (HRT), contraception, and treatment of various estrogen deficiency conditions. Known for its potent estrogenic activity and structural identity to naturally occurring estradiol, Estradiol Anhydrous is widely used in gynaecology, endocrinology, and women's health formulations.

This API appears as a white to off-white crystalline powder with limited water solubility but good stability under controlled storage conditions. Its mechanism—binding to estrogen receptors alpha and beta—mediates genomic and non-genomic effects that regulate reproductive function, bone metabolism, cardiovascular health, and numerous other physiological processes.

Related products include Estradiol Valerate, Estradiol Hemihydrate, Conjugated Estrogens, and other hormone replacement therapy agents used in menopausal symptom management and hormonal disorders. It may be combined with L-Glutamine in some nutritional support formulations for women's health.

Applications of Estradiol Anhydrous

Pharmaceutical API

• Used in hormone replacement therapy for menopausal symptoms
• Effective in treating vasomotor symptoms (hot flashes, night sweats)
• Applied in the prevention and treatment of postmenopausal osteoporosis
• Used for hypoestrogenism due to various causes (hypogonadism, ovarian failure)
• Component of oral contraceptive formulations
• Applied in the treatment of vulvovaginal atrophy

Formulation Development

• U used in transdermal patches topical gels, vaginal preparations
• It is available in immediate release and extended-release versions
• Transdermal delivery systems provide steady-state levels, avoiding first-pass metabolism
• Most often, progestins are included in formulations of HRT
• Multiple delivery routes allow dose optimisation
• Stable when properly designed products that provide moisture protection

Gynaecological & Endocrine Treatment

• Reduces symptoms of menopausal while improving the quality of your life
• Maintains bone mineral density, reducing fracture risk
• Enhances the urogenital signs and sexual functions
• Helps improve cardiovascular health when it is initiated earlier in menopausal
• It is bioidentical to estradiol from the body (better then synthesized estrogens)
• The ability to dose according to the individual needs of each patient

Safety & Handling Guidelines

• Potent hormone—avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Handle in controlled environments with appropriate containment
• Store in a cool, dry place protected from light and moisture
• Keep away from heat and oxidising agents
• Follow COA and MSDS instructions strictly

Where to Buy Estradiol Anhydrous?

Estradiol Anhydrous Manufacturer

ChemicalBull supplies high-purity Estradiol Anhydrous API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Estradiol Anhydrous Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• Requires controlled handling and storage
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Estradiol Anhydrous?
   

   Estradiol Anhydrous is the water-free (anhydrous) form of 17β-estradiol, the primary and most potent naturally occurring estrogen hormone in humans.
   
   

2. What is Estradiol Anhydrous used for?
   

   It is used for hormone replacement therapy in menopausal women, treatment of estrogen deficiency, prevention of osteoporosis, and management of various gynaecological conditions.
   
   

3. What is the difference between Estradiol Anhydrous and Estradiol Hemihydrate?
   

   The primary difference is water content: the anhydrous form contains no water molecules, while the hemihydrate contains 0.5 water molecules per estradiol molecule.