Calcium Folinate | 1492-18-8

Description :

Overview of Calcium Folinate

Calcium Folinate is a pharmaceutical-grade reduced folate compound that is derived from calcium and folinic acid. It is chemically different from folic acid and does not require enzyme reduction to achieve biological activity, which makes it suitable for specific therapeutic or rescue applications.

In the manufacturing of pharmaceuticals, Calcium Folinate is valued because of its definite chemical structure, bioactivity, and its compatibility with oral and injectable dosage forms. Calcium folinate is a pharmaceutical chemical that is produced in India and is manufactured under GMP conditions to ensure quality, stability, and regulations.

As a pharma chemical, Calcium Folinate is used primarily in oncology support therapy and folate-related metabolic formulations.

Applications of Calcium Folinate

Pharmaceutical API & Therapeutic Formulations

Calcium Folinate is used as an active pharmaceutical ingredient in regulated formulations where biologically active folate supplementation is required. It is commonly incorporated into injectable and oral products used in specialised therapeutic protocols.

In oncology-related formulation development, it is often evaluated alongside Methotrexate to support controlled therapeutic regimens.

Pharmaceutical Chemistry & Structural Characteristics

From a chemistry standpoint, the calcium folinate form of pharmaceuticals is composed of a Pteroylglutamic Acid derivative bonded to calcium. The reduced form permits direct involvement in the folate-dependent metabolic pathways, without any prior enzymatic activation.

Calcium folinate synthesis involves controlled chemical reduction and salt formation processes to ensure stereochemical integrity and pharmaceutical-grade purity.

Industrial & Regulated Manufacturing Use

Calcium Folinate is produced as a highly pure pharmaceutical raw material that has strict control of isomeric composition as well as impurities and the limits of microbial growth. The material is suitable for manufacturing sterile and pharmaceutical supply chains that are controlled.

In folate-based formulation studies, it may be referenced alongside Folic Acid and vitamin-related compounds such as Methylcobalamin for compatibility and therapeutic alignment.

Safety & Handling Guidelines

• Store in a cool, dry, and controlled environment
• Protect from light and moisture
• Keep containers tightly sealed and clearly labelled
• Avoid inhalation of dust during handling
• Make sure you have the appropriate personal protection equipment
• Handle under controlled manufacturing conditions
• Waste disposal is governed by the regulations.
  
  
  

Where to Buy Calcium Folinate?

Calcium Folinate Manufacturer

Calcium Folinate is manufactured for pharmaceutical applications where controlled synthesis, reduced folate activity, and regulatory compliance are essential.

Calcium Folinate Supplier & Distributor

Pharmaceutical-grade Calcium Folinate is supplied in suitable packaging for formulation manufacturers. As a pharmaceutical chemicals supplier and distributor, Chemicalbull Pvt. Ltd. supports reliable sourcing with standard documentation.

MSDS for Calcium Folinate

The MSDS for Calcium Folinate provides information on the handling and storage precautions, as well as storage conditions, exposure control, and emergency procedures. It is important to read it before using it in the pharmaceutical manufacturing process.

Frequently Asked Questions (FAQs)

1. What is Calcium Folinate used for?
   

   Calcium Folinate is a component of pharmaceutical formulations that require folate that is biologically active, especially in support of oncology as well as metabolic therapies.
   
   

2. What is the structure of Calcium Folinate?
   

   Calcium folinate structure is based on a reduced folate molecule complexed with calcium, allowing direct metabolic activity.
   
   

3. How is Calcium Folinate synthesised?
   

   Calcium folinate synthesis involves chemical reduction of folate derivatives followed by controlled calcium salt formation under regulated conditions.