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Tert-butoxides, specifically referring to tert-butoxide ions (tert-BuO⁻), are chemical species derived from tert-butanol through the removal of a proton. Tert-butoxides are strong bases and nucleophiles due to the presence of the negatively charged oxygen atom. The tert-butoxide ion is often employed in organic synthesis and catalysis. Its strong basic nature makes tert-butoxide a useful reagent in deprotonation reactions, where it abstracts protons from acidic compounds, facilitating the formation of carbon-carbon or carbon-heteroatom bonds. This reactivity is particularly valuable in organic chemistry for the synthesis of various compounds. Tert-butoxides are frequently used in Williamson ether synthesis, where they participate in the formation of ethers by reacting with alkyl halides or sulfonates. Additionally, they find application in elimination reactions, such as the E2 elimination, which promotes the removal of a proton and a leaving group from adjacent carbons. Despite their utility, tert-butoxides should be handled with care, as they are highly reactive and sensitive to moisture. Their precise control and strategic use in chemical reactions contribute to the efficiency and diversity of synthetic processes in organic chemistry.