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Disease-modifying antirheumatic medicines (DMARDs) are a class of medications predominantly used to treat autoimmune illnesses, including rheumatoid arthritis. These medications act by altering the underlying disease process rather than simply treating symptoms. Individuals with chronic inflammatory disorders benefit greatly from DMARDs because they help manage inflammation, avoid joint degeneration, and improve overall quality of life. Methotrexate, sulfasalazine, and hydroxychloroquine are examples of standard synthetic DMARDs. Methotrexate, a key component of rheumatoid arthritis treatment, works by decreasing folate metabolism, which suppresses the immunological response that causes joint inflammation. Sulfasalazine, a combination of an anti-inflammatory and a sulfa antibiotic, has been shown to be effective in the treatment of joint problems. Hydroxychloroquine, originally created as an antimalarial medication, has immunomodulatory effects that help people with autoimmune illnesses. Biologic DMARDs are another family of drugs that target specific immune system components. Tumor necrosis factor (TNF) inhibitors such as adalimumab and etanercept block TNF, a major cytokine in inflammatory responses. Other biologics, such as rituximab and abatacept, target B and T cells, respectively, to regulate immune system activity and reduce inflammation. Janus kinase (JAK) inhibitors are a newer type of DMARD, providing an oral option to injectable biologics. JAK enzymes are implicated in signaling pathways that lead to inflammation, and drugs such as tofacitinib and baricitinib block them. This technique offers another choice for people who prefer oral drugs to injections. While DMARDs have considerably improved the outcomes for many patients with autoimmune disorders, their usage is not without risks. Regular monitoring is required to detect adverse responses or changes in blood parameters. Furthermore, healthcare experts customize treatment programs based on individual needs, taking into account illness severity, comorbidities, and patients' preferences. In conclusion, DMARDs are a broad set of drugs that have transformed the treatment of autoimmune illnesses by targeting the underlying processes of inflammation. Their introduction has resulted in improved symptom control, functional outcomes, and a better overall prognosis for people suffering from chronic inflammatory diseases.