Trimethylsilyl Bromide | 2857-97-8

Description :

Overview of Trimethylsilyl Bromide

Trimethylsilyl Bromide (TMSBr) Trimethylsilyl Bromide (TMSBr) is an active silylating and deprotecting substance that is used in organic syntheses. The agent is known for its ability to degrade esters and ethers, to introduce trimethylsilyl compounds, and for its superior reaction with functional groups containing oxygen. TMSBr is widely used for pharmaceutical synthesis as well as deprotection reactions and the production of specialty chemicals.

This compound appears as a colorless liquid. Its trimethylsilyl bromide structure provides unique reactivity for both silylation and cleavage reactions.

Related products include Trimethylsilyl Chloride, Trimethylsilyl Iodide, and other silylating agents used in organic synthesis.

Applications of Trimethylsilyl Bromide

Pharmaceutical Synthesis

• Used in cleaving methyl ethers to phenols
• Applied in the deprotection of ester groups
• Used in pharmaceutical intermediate production

Industrial Organic Synthesis

• Used as a silylating reagent
• Applied in organic synthesis reactions
• Used in manufacturing chemical intermediates

Research Applications

• Used in academic research laboratories
• Applied in organic chemistry methodology

Safety & Handling Guidelines

• HIGHLY REACTIVE—moisture sensitive
• CORROSIVE—causes burns
• Avoid inhalation of vapors
• Use gloves, goggles, and protective clothing
• Handle under anhydrous conditions in a fume hood
• Store in tightly sealed containers under inert gas
• Keep away from moisture, water, and bases
• Follow COA and MSDS instructions strictly

Where to Buy Trimethylsilyl Bromide?

Trimethylsilyl Bromide Manufacturer

ChemicalBull supplies high-purity Trimethylsilyl Bromide for pharmaceutical and research applications.

Trimethylsilyl Bromide Supplier & Distributor

• It is available in limited amounts for research and pharmaceutical usage.
• Pure anhydrous grade (97%, 98percent)
• Packaging with special moisture resistance with an inert gas
• COA MSDS, as well as full Safety documentation, is available

MSDS

includes comprehensive warnings about reactivity and handling protocol.

Frequently Asked Questions (FAQs)

1. What is Trimethylsilyl Bromide used for?
   

   Used for cleaving ethers and esters, deprotection reactions, and introducing trimethylsilyl groups in pharmaceutical synthesis.
   
   

2. What is the molecular formula?
   

   Molecular formula: C₃H₉BrSi with molecular weight 153.10 g/mol.
   
   

3. How does it cleave ethers?
   

   Bromide acts as a nucleophile while the silyl group activates the ether oxygen; it cleaves methyl ethers, forming phenols and methyl bromide.