Triethyl Phosphonoacetate | 867-13-0
Cas No :
867-13-0
Form :
Liquid
Molecular Weight :
224.19 G/Mol
Molecular Formula :
C8H17O5P
Boiling Point :
142 - 145 °C
Melting Point :
-20 °C
Flash Point :
105 °C
Solubility :
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Description :
Overview of Triethyl Phosphonoacetate
Triethyl Phosphonoacetate is a phosphonate ester used as a reagent in organic synthesis, particularly in Horner-Wadsworth-Emmons reactions. Known for its use in forming carbon-carbon double bonds, applications in pharmaceutical synthesis, and role as a Wittig-type reagent, Triethyl Phosphonoacetate is widely used in pharmaceutical manufacturing, specialty chemical production, and research applications.
This compound appears as a colorless to pale yellow liquid. Its phosphonoacetate structure provides useful reactivity for olefination reactions.
Related products include other phosphonates, Wittig reagents, and ylide precursors used in organic synthesis. Works complementarily with Tetramethylammonium Bromide in some synthetic procedures.
Applications of Triethyl Phosphonoacetate
Pharmaceutical Synthesis
- Used in Horner-Wadsworth-Emmons olefination
- Utilized in the production of pharmaceutical intermediates
- Utilized in the synthesis of potential drug compounds
Industrial Organic Synthesis
- used in the production of special chemicals
- Utilized in organic synthesis reactions
- Utilized in the manufacture of chemical intermediates
Research Applications
- Utilized in research labs
- Used in organic chemistry methods
- Used in developing synthetic routes
Safety & Handling Guidelines
- Avoid inhalation of vapors
- Use gloves, goggles, and protective clothing
- Handle in a well-ventilated fume hood
- Store in tightly closed containers in a cool place
- Keep away from strong oxidizers and bases
- Follow COA and MSDS instructions strictly
Where to Buy Triethyl Phosphonoacetate?
Triethyl Phosphonoacetate Manufacturer
ChemicalBull supplies high-purity Triethyl Phosphonoacetate for pharmaceutical and research applications.
Triethyl Phosphonoacetate Supplier & Distributor
- Available in bulk quantities for pharmaceutical and research use
- High-purity grades (97%, 98%)
- COA, MSDS, and specifications provided
MSDS
Includes detailed safety instructions and handling protocols.
Frequently Asked Questions (FAQs)
-
What is Triethyl Phosphonoacetate used for?
Used primarily in Horner-Wadsworth-Emmons reactions for forming C=C bonds in pharmaceutical synthesis. -
What is the molecular formula?
Molecular formula: C₈H₁₇O₅P with molecular weight 224.19 g/mol. -
What is an HWE reaction?
Horner-Wadsworth-Emmons: phosphonate ester reacts with aldehydes/ketones, forming α,β-unsaturated esters; an alternative to Wittig.
