Tizanidine Hydrochloride | 64461-82-1

Description :

Overview of Tizanidine Hydrochloride

Tizanidine Hydrochloride is a centrally acting alpha-2 adrenergic agonist used as a muscle relaxant for treating spasticity associated with multiple sclerosis, spinal cord injury, and other neurological conditions. Known for its effectiveness in reducing muscle tone without significant loss of muscle strength, Tizanidine Hydrochloride is widely used in neurology and rehabilitation medicine.

This API appears as a white to off-white crystalline powder with characteristic properties. Its mechanism—agonism of alpha-2 adrenergic receptors in the CNS—reduces spasticity by increasing presynaptic inhibition of motor neurons and decreasing excitatory neurotransmitter release.

Related products include Baclofen, Cyclobenzaprine, Dantrolene, and other muscle relaxants used in spasticity and muscle spasm management.

Applications of Tizanidine Hydrochloride

Pharmaceutical API

• Used in antispasticity medications
• Effective in treating spasticity from multiple sclerosis
• Applied to spinal cord injury-related spasticity
• Used for cervical dystonia and other movement disorders
• Applied to chronic musculoskeletal pain with muscle spasm
• Off-label use in tension headaches and migraines

Formulation Development

• Utilized in tablets with immediate release as well as capsules
• Available in multiple strengths (2, 4, 6 mg)
• The short half-life of requires several daily doses or sustained-release formulations
• Bioavailability is a major factor in food.
• Stable in solid dosage forms
• Generic formulations available

Neurological Treatment

• Reducing muscle spasticity but without causing weakness
• Enhances mobility and day-to-day use
• allows participation in physical therapy
• Flexible dosing based on patient response
• can be adjusted to ensure that efficacy is balanced with the risk of sedation
• The short-term duration of HTML0 allows "as required" usage for certain patients

Handling and Safety Guidelines

• Beware of inhaling fine powder
• Wear gloves, goggles, and appropriate clothing when handling
• Place in a dry, cool location away from humidity
• Use the COA as well as the MSDS guidelines completely

Where to Buy Tizanidine Hydrochloride?

Tizanidine Hydrochloride Manufacturer

ChemicalBull supplies high-purity Tizanidine Hydrochloride API, meeting IP/EP/USP quality standards for pharmaceutical formulations.

Tizanidine Hydrochloride Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Tizanidine Hydrochloride used for?
   

   Used for treating muscle spasticity associated with multiple sclerosis, spinal cord injury, stroke, cerebral palsy, and other neurological conditions causing increased muscle tone.
   
   

2. How does Tizanidine work?
   

   It acts as an alpha-2 adrenergic agonist in the CNS, reducing the release of excitatory neurotransmitters and decreasing polysynaptic reflex activity, thereby reducing muscle spasticity.
   
   

3. What is the typical dosage?
   

   Starting dose: 2-4 mg at bedtime; gradually titrated up to 8 mg three times daily or higher (max 36 mg/day) based on response and tolerability.