Tert-butyldimethylsilyl Chloride | 18162-48-6

Description :

Overview of Tert-Butyldimethylsilyl Chloride

Tert-Butyldimethylsilyl Chloride (TBDMSCl) is a highly efficient silylating and protecting-group reagent, widely used in pharmaceutical synthesis, API development, fine chemicals, and research laboratories. Known for its strong ability to protect alcohols, phenols, and amines, it ensures safe multi-step synthesis without unwanted side reactions.

With excellent stability, high selectivity, and compatibility with various bases and solvents, Tert-Butyldimethylsilyl Chloride is one of the most preferred silylating agents in modern organic chemistry.

On ChemicalBull, related products like Chloromethyl Chlorosulfate, Dodecyltrimethoxysilane, Tetradecane, and Diisobutylamine 

Applications of Tert-Butyldimethylsilyl Chloride

Pharmaceutical Synthesis

• Used as a protecting reagent during multi-step API development

• Ensures selective protection of alcohols & amines

• Used in peptide synthesis, chiral molecules & complex drug intermediates

Organic Synthesis & Research

• Protects hydroxyl groups in synthetic pathways

• High compatibility with strong bases like imidazoles & pyridines

• Widely used in academic & industrial chemical R&D

Fine Chemicals Manufacturing

• Helps maintain reaction efficiency

• Protects functional groups during high-temperature reactions

• Common in production of fragrances, agro intermediates & specialty chemicals

Polymer & Surface Chemistry

• Used in advanced material synthesis

• Enhances hydrophobicity of surfaces through silylation

• Useful in modifying silica, fillers & polymer backbones

Safety & Handling Guidelines

• Handle with gloves, goggles & proper ventilation

• Avoid moisture contact — TBDMSCl is moisture-sensitive

• Keep container tightly closed to prevent hydrolysis

• Store in a cool, dry, and well-ventilated area

• Refer to MSDS for hazard, toxicity & spill response information

Where to Buy Tert-Butyldimethylsilyl Chloride?

Tert-Butyldimethylsilyl Chloride Manufacturer

Produced in high-purity, pharma-grade, and industrial-grade suitable for synthesis applications.

Tert-Butyldimethylsilyl Chloride Supplier & Exporter

ChemicalBull supplies TBDMSCl with:

• COA & MSDS

• Export documentation

• Safe HDPE drum packing

• Global shipping support

Tert-Butyldimethylsilyl Chloride MSDS

• Physical & chemical data

• Reactivity & stability

• Personal protection guidelines

• First-aid & storage instructions

Frequently Asked Questions (FAQs)

1. What is Tert-Butyldimethylsilyl Chloride used for?

   It is used as a protecting group reagent in pharmaceutical and organic synthesis for alcohols, phenols & amines.
   
   

2. Is Tert-Butyldimethylsilyl Chloride moisture-sensitive?

   Yes, it reacts with moisture and must be stored in a dry, sealed container.
   
   

3. Do you supply pharma-grade Tert-Butyldimethylsilyl Chloride?

   Yes, ChemicalBull provides high-purity pharma-grade and industrial-grade Tert-Butyldimethylsilyl Chloride.
   
   

4. Can it be used for multi-step synthesis?

   Absolutely, it is ideal for protecting functional groups during complex multi-step chemical reactions.
   
   

5. Do you provide COA, MSDS & export packing?

   Yes, every shipment includes COA, MSDS, and export documentation.

ChemicalBull supplies Tert-butyldimethylsilyl Chloride across India, serving customers in Andhra Pradesh, Arunachal Pradesh, Assam, Bihar, Chhattisgarh, Goa, Gujarat, Haryana, Himachal Pradesh, Jharkhand, Karnataka, Kerala, Madhya Pradesh, Maharashtra, Manipur, Meghalaya, Mizoram, Nagaland, Odisha, Punjab, Rajasthan, Sikkim, Tamil Nadu, Telangana, Tripura, Uttar Pradesh, Uttarakhand, and West Bengal, as well as the Union Territories of Andaman & Nicobar Islands, Chandigarh, Dadra & Nagar Haveli and Daman & Diu, Delhi, Jammu & Kashmir, Ladakh, Lakshadweep, and Puducherry. We serve pharmaceutical, chemical, research, academic, laboratory, manufacturing, and industrial customers with reliable nationwide delivery.