Tert-Butyldimethylsilyl Chloride | 18162-48-6

Description :

Overview of Tert-Butyldimethylsilyl Chloride

Tert-Butyldimethylsilyl Chloride (TBDMSCl) is a highly efficient silylating and protecting-group reagent, widely used in pharmaceutical synthesis, API development, fine chemicals, and research laboratories. Known for its strong ability to protect alcohols, phenols, and amines, it ensures safe multi-step synthesis without unwanted side reactions.

With excellent stability, high selectivity, and compatibility with various bases and solvents, Tert-Butyldimethylsilyl Chloride is one of the most preferred silylating agents in modern organic chemistry.

On ChemicalBull, related products like Chloromethyl Chlorosulfate, Dodecyltrimethoxysilane, Tetradecane, and Diisobutylamine 

Applications of Tert-Butyldimethylsilyl Chloride

Pharmaceutical Synthesis

• Used as a protecting reagent during multi-step API development

• Ensures selective protection of alcohols & amines

• Used in peptide synthesis, chiral molecules & complex drug intermediates

Organic Synthesis & Research

• Protects hydroxyl groups in synthetic pathways

• High compatibility with strong bases like imidazoles & pyridines

• Widely used in academic & industrial chemical R&D

Fine Chemicals Manufacturing

• Helps maintain reaction efficiency

• Protects functional groups during high-temperature reactions

• Common in production of fragrances, agro intermediates & specialty chemicals

Polymer & Surface Chemistry

• Used in advanced material synthesis

• Enhances hydrophobicity of surfaces through silylation

• Useful in modifying silica, fillers & polymer backbones

Safety & Handling Guidelines

• Handle with gloves, goggles & proper ventilation

• Avoid moisture contact — TBDMSCl is moisture-sensitive

• Keep container tightly closed to prevent hydrolysis

• Store in a cool, dry, and well-ventilated area

• Refer to MSDS for hazard, toxicity & spill response information

Where to Buy Tert-Butyldimethylsilyl Chloride?

Tert-Butyldimethylsilyl Chloride Manufacturer

Produced in high-purity, pharma-grade, and industrial-grade suitable for synthesis applications.

Tert-Butyldimethylsilyl Chloride Supplier & Exporter

ChemicalBull supplies TBDMSCl with:

• COA & MSDS

• Export documentation

• Safe HDPE drum packing

• Global shipping support

Tert-Butyldimethylsilyl Chloride MSDS

• Physical & chemical data

• Reactivity & stability

• Personal protection guidelines

• First-aid & storage instructions

Frequently Asked Questions (FAQs)

1. What is Tert-Butyldimethylsilyl Chloride used for?

   It is used as a protecting group reagent in pharmaceutical and organic synthesis for alcohols, phenols & amines.
   
   

2. Is Tert-Butyldimethylsilyl Chloride moisture-sensitive?

   Yes, it reacts with moisture and must be stored in a dry, sealed container.
   
   

3. Do you supply pharma-grade Tert-Butyldimethylsilyl Chloride?

   Yes, ChemicalBull provides high-purity pharma-grade and industrial-grade Tert-Butyldimethylsilyl Chloride.
   
   

4. Can it be used for multi-step synthesis?

   Absolutely, it is ideal for protecting functional groups during complex multi-step chemical reactions.
   
   

5. Do you provide COA, MSDS & export packing?

   Yes, every shipment includes COA, MSDS, and export documentation.