Sodium Bis(Trimethylsilyl)Amide
Description :
Overview of Sodium Bis(Trimethylsilyl)Amide
Sodium Bis(Trimethylsilyl)Amide (NaHMDS, NaN(TMS)₂) is a strong, non-nucleophilic base used extensively in organic synthesis, pharmaceutical manufacturing, and polymer chemistry.
Known for its excellent basicity combined with steric bulk preventing unwanted side reactions, NaHMDS is widely used in pharmaceutical synthesis, generating enolates and organometallic compounds, and various deprotonation reactions.
This compound appears as a white to off-white powder or is supplied as a solution in THF, toluene, or hexane. Its bulky trimethylsilyl groups provide a strong base character while minimizing nucleophilicity.
Related products include Lithium Bis(trimethylsilyl)amide (LiHMDS), Potassium Bis(trimethylsilyl)amide (KHMDS), and other strong non-nucleophilic bases used in organic synthesis. Works complementarily with Cyclohexene Oxide and Dodecyltrimethoxysilane in silane chemistry.
Applications of Sodium Bis(Trimethylsilyl)Amide
Pharmaceutical Synthesis
- Utilized to generate the enolates needed for aldol reactions
- Used in the synthesis of pharmaceutical intermediates
- It is used in stereoselective synthesis.
Industrial Organic Synthesis
- used for deprotonation reactions
- Used in anionic polymerization
- It is used in the preparation of organic compounds
- It is used to synthesize specialty chemical S
Advanced Transformations
- Used in C-C bond-forming reactions
- Applied in Claisen condensations
- Used in Michael's additions
- Applied in heterocyclic synthesis
Safety & Handling Guidelines
- HIGHLY REACTIVE and PYROPHORIC—extreme caution required
- Reacts violently with water, oxygen, and protic solvents
- Use only under strictly anhydrous conditions and an inert atmosphere
- Handle in the glove box or using Schlenk techniques
- Wear full PPE, including chemical-resistant gloves, face shield
- Store in tightly sealed containers under argon or nitrogen
Where to Buy Sodium Bis(Trimethylsilyl)Amide?
Sodium Bis(Trimethylsilyl)Amide Manufacturer
ChemicalBull supplies high-purity Sodium Bis(Trimethylsilyl)Amide for pharmaceutical and research applications.
Sodium Bis(Trimethylsilyl)Amide Supplier & Distributor
- Available as powder or solution in THF, hexanes, toluene
- Multiple concentration options (1M, 2M in various solvents)
- High-purity grades for pharmaceutical synthesis
- Packaged under an inert atmosphere
- COA, MSDS, and comprehensive safety documentation provided
MSDS
Includes comprehensive pyrophoric handling instructions and emergency procedures.
Frequently Asked Questions (FAQs)
-
What is the Sodium bis trimethylsilyl amide formula?
Molecular formula: C₆H₁₈NNaSi₂ or NaN(Si(CH₃)₃)₂ with molecular weight 183.37 g/mol. -
What is Sodium bis(trimethylsilyl)amide, CAS No?
CAS number: 1070-89-9. -
What is Sodium Bis(Trimethylsilyl)Amide used for?
Used as a strong non-nucleophilic base for deprotonation, enolate generation, pharmaceutical synthesis, and anionic polymerization.
