Pramoxine Hydrochloride | 637-58-1

Description :

Overview of Pramoxine Hydrochloride

Pramoxine Hydrochloride can be described as a topical local anaesthetic which is utilised to reduce itching and pain that is caused by minor skin irritations, haemorrhoids and mucosal lesions. It is renowned for its non-sensitising properties and its lack of cross-reactivity with anaesthetics made of amide and ester; Pramoxine Hydrochloride is widely employed in dermatological and anorectal formulations.

This API appears as a white to off-white crystalline powder with good water solubility and stability. Its mechanism—stabilisation of neuronal membranes by inhibiting sodium ion influx—blocks pain signal transmission, providing rapid, temporary relief from pain and itching.

Related products include Lidocaine, Benzocaine, Dibucaine, and other local anaesthetics used in topical pain relief and dermatological applications.

Applications of Pramoxine Hydrochloride

Pharmaceutical API

• Used in topical anaesthetic formulations for pain and itch relief
• Effective in treating minor burns, sunburn, and skin irritations
• Applied in haemorrhoid treatment (internal and external)
• Used for pruritus ani and other anorectal disorders
• Relieves pain from minor cuts, scrapes, and insect bites

Formulation Development

• Used in creams, ointments, gels, foams, and suppositories
• Available in spray formulations for easy application
• Often combined with hydrocortisone for enhanced anti-inflammatory effects
• May be combined with Ibuprofen in certain topical formulations
• Compatible with various topical bases
• Stable in properly formulated products

Dermatological & Anorectal Treatment

• Provides rapid onset of action (3-5 minutes)
• Non-allergenic—suitable for patients sensitive to other anaesthetics
• Does not cause cross-sensitivity reactions
• Suitable for mucous membranes and broken skin
• Well-tolerated with minimal systemic absorption

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Store in a cool, dry place away from light and moisture
• Follow COA and MSDS instructions strictly

Where to Buy Pramoxine Hydrochloride?

Pramoxine Hydrochloride Manufacturer

ChemicalBull supplies high-purity Pramoxine Hydrochloride API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Pramoxine Hydrochloride Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Provides detailed safety guidelines as well as hazard identification and storage requirements.

Frequently Asked Questions (FAQs)

1. What's Pramoxine Hydrochloride's use?
   

   It's used to provide short-term relief from itching and pain from minor burns, skin irritations or haemorrhoids. It can also be used to treat the anorectal region.
   
   

2. Is Pramoxine safe for sensitive skin?
   

   It is non-allergenic and is not in contact with other local anaesthetics, which makes it safe for sensitive people.
   
   

3. How long does Pramoxine take to work?
   

   It typically provides relief within 3-5 minutes of application, with effects lasting several hours.