N,O-Bis-Trimethylsilyl Acetamide | 10416-59-8

Description :

Overview of N, O-Bis Trimethylsilyl Acetamide

N O-Bis Trimethylsilyl Acetamide (BSA) is a potent silylating reagent that is used to safeguard and desalinate compounds used for analytical chemistry, organic synthesis, and the pharmaceutical industry.

Known for its ability to introduce trimethylsilyl groups onto active hydrogens, volatility enabling easy removal, and use in GC-MS sample preparation, BSA is widely used in analytical laboratories, pharmaceutical synthesis, and chemical research.

This compound appears as a colorless liquid with a characteristic odor. Its dual silylating capability provides efficient protection of both N-H and O-H groups simultaneously.

Related products include N, O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA), Trimethylsilyl Chloride, and other silylating agents used in analytical and synthetic chemistry. Works complementarily with Cyclohexene Oxide and Dodecyltrimethoxysilane in silane chemistry applications.

Applications of N, O-Bis Trimethylsilyl Acetamide

Analytical Chemistry

• Used in GC-MS sample derivatization
• Applied in preparing volatile derivatives for analysis
• Used in amino acid analysis
• Applied in carbohydrate analysis

Pharmaceutical Synthesis

• Used as a silylating reagent in drug synthesis
• Applied in protecting hydroxyl and amino groups
• Used in pharmaceutical intermediate preparation
• Applied in peptide synthesis

Industrial & Research Applications

• Used in organic synthesis methodology
• Applied in materials chemistry research
• Used in polymer chemistry applications
• Applied in surface modification studies

Safety & Handling Guidelines

• MOISTURE SENSITIVE—reacts with water
• Flammable liquid—keep away from ignition sources
• Avoid inhalation of vapors
• Use gloves, goggles, and protective clothing
• Handle in a well-ventilated fume hood
• Handle under anhydrous conditions

Where to Buy N, O-Bis Trimethylsilyl Acetamide?

N, O-Bis Trimethylsilyl Acetamide Manufacturer

ChemicalBull supplies high-purity N, O-Bis Trimethylsilyl Acetamide for analytical and pharmaceutical applications.

N, O-Bis Trimethylsilyl Acetamide Supplier & Distributor

• Available in bulk quantities for analytical and pharmaceutical use
• High-purity anhydrous grades (≥99%)
• Packaged under an inert atmosphere
• COA, MSDS, and specifications provided

MSDS

Includes detailed moisture sensitivity warnings, flammability data, and handling protocols.

Frequently Asked Questions (FAQs)

1. What is the N o bis trimethylsilyl acetamide structure?
   

   Acetamide with both nitrogen and oxygen protected by trimethylsilyl groups: (CH₃)₃Si-N(Si(CH₃)₃)-CO-CH₃.
   
   

2. What are N o bis trimethylsilyl acetamide uses?
   

   Used in GC-MS derivatization, protecting hydroxyl and amino groups in synthesis, pharmaceutical intermediate preparation, and analytical chemistry.
   
   

3. What is N, O-Bis Trimethylsilyl Acetamide used for?
   

   Used primarily for silylating active hydrogens (OH, NH, SH) in analytical samples and synthetic intermediates to improve volatility and stability.