N-Iodosuccinimide
Description :
Overview of N-Iodosuccinimide
N-Iodosuccinimide (NIS) is an iodinating reagent used extensively in organic synthesis, pharmaceutical manufacturing, and chemical research. Known for its mild and selective iodination capabilities, electrophilic properties, and ease of handling compared to elemental iodine, N-Iodosuccinimide is widely used in pharmaceutical synthesis, introducing iodine into organic molecules, and various oxidation reactions.
This compound appears as a white to pale yellow crystalline powder.
Its N-iodoimidazole structure provides controlled release of electrophilic iodine species, making it an invaluable reagent for selective iodination and oxidation reactions.
Related products include N-Bromosuccinimide (NBS), N-Chlorosuccinimide (NCS), Isoamyl Bromide, and other halogenating agents used in organic synthesis and pharmaceutical chemistry.
Applications of N-Iodosuccinimide
Pharmaceutical Synthesis
- Used in iodinating aromatic compounds
- Applied in synthesising iodinated pharmaceutical intermediates
- Used in preparing thyroid hormone analogues
- Applied in manufacturing radio-iodinated compounds
- Used in introducing iodine into drug molecules
- Applied in medicinal chemistry research
- Used in developing pharmaceutical APIs
- Applied in fine pharmaceutical production
Industrial Organic Synthesis
- Used in electrophilic iodination reactions
- Applied in halolactonization reactions
- Used in the oxidation of alcohols and sulfides
- Applied in glycosidation reactions
- Used in synthesising heterocyclic compounds
- Applied in preparing speciality chemicals
- Used in total synthesis programs
- Applied in developing synthetic methodologies
Chemical Research & Development
- Used in academic research laboratories
- Applied in studying reaction mechanisms
- Used in developing new synthetic routes
- Applied in materials chemistry research
- Used in chemical biology investigations
- Applied in drug discovery programs
- Used in polymer chemistry applications
- Applied in industrial R&D initiatives
Safety & Handling Guidelines
- OXIDIZING AGENT—may intensify fire
- IRRITANT—avoid inhalation and skin contact
- Use gloves, goggles, and protective clothing
- Handle in a well-ventilated fume hood
- Store in tightly closed containers in a cool, dry place
- Keep away from reducing agents and combustible materials
- Protect from light and moisture
- Dispose of according to hazardous waste protocols
- Follow COA and MSDS instructions strictly
Where to Buy N-Iodosuccinimide?
N-Iodosuccinimide Manufacturer
ChemicalBull supplies high-purity N-Iodosuccinimide for pharmaceutical and research applications.
Supplier & Distributor
- Available in bulk quantities for pharmaceutical and research use
- High-purity grades (95%, 97%, 99%)
- Pharmaceutical and research grades
- Protected packaging (light-resistant)
- COA, MSDS, and specifications provided
MSDS
Includes detailed safety instructions, oxidiser warnings, and handling protocols.
Frequently Asked Questions (FAQs)
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What is N-Iodosuccinimide used for?
Used as an electrophilic iodinating reagent in organic synthesis, pharmaceutical intermediate preparation, oxidation reactions, glycosidation, and the introduction of iodine atoms into molecules. -
What is the molecular formula?
Molecular formula: C₄H₄INO₂ with molecular weight 224.98 g/mol. -
How does NIS work as an iodinating agent?
Releases electrophilic iodine (I⁺) species that react with nucleophilic sites (aromatic rings, alkenes, heteroatoms), introducing iodine atoms.Overview of Diallyldimethylammonium Chloride
