Letrozole | 112809-51-5

Description :

Overview of Letrozole

Letrozole is an aromatase inhibitor for the treatment of hormone receptor-positive breast cancer in postmenopausal women. The drug is known for its potency and specific aromatase inhibitor, Letrozole, is widely used in the field of oncology to treat estrogen-dependent cancers and enhance fertility.

This API appears as a white to yellowish crystalline powder with good stability under standard storage conditions. Its mechanism—inhibition of the aromatase enzyme complex—blocks the conversion of androgens to estrogens, effectively suppressing estrogen levels in postmenopausal women.

Related products include Anastrozole, Exemestane, Tamoxifen, and other hormonal anticancer agents used in breast cancer therapy and fertility treatment.

Applications of Letrozole

Pharmaceutical API

• Used in hormonal anticancer medications
• Effective as a first-line treatment for hormone receptor-positive breast cancer
• Used in adjuvant, extended adjuvant, and metastatic breast cancer settings
• Off-label use in ovulation induction for fertility treatment

Formulation Development

• Used in film-coated tablets
• Suitable for once-daily dosing
• Offers excellent chemical stability
• Low-dose formulations (typically 2.5 mg)

Oncological & Fertility Treatment

• Significantly reduces breast cancer recurrence risk
• Improves disease-free and overall survival in breast cancer patients
• Enhances ovulation in women with polycystic ovary syndrome (PCOS)
• Better bone safety profile than some older aromatase inhibitors

Safety & Handling Guidelines

• Avoid inhalation of fine powder
• Use gloves, goggles, and protective clothing during handling
• Potent API—handle in controlled environments
• Store in a cool, dry place away from light and moisture
• Follow COA and MSDS instructions strictly

Where to Buy Letrozole?

Letrozole Manufacturer

ChemicalBull supplies high-purity Letrozole API that meets IP/EP/USP quality standards for pharmaceutical formulations.

Letrozole Supplier & Distributor

• Available in bulk packing for formulation units
• Stable and high-purity grade for research and production
• COA, MSDS, and regulatory documents provided

MSDS

Includes detailed safety instructions, hazard identification, and storage guidelines.

Frequently Asked Questions (FAQs)

1. What is Letrozole used for?
   

   It is primarily used for treating hormone receptor-positive breast cancer in postmenopausal women and for ovulation induction in fertility treatment.
   
   

2. How does Letrozole differ from Tamoxifen?
   

   Letrozole is an aromatase inhibitor that blocks estrogen production, while Tamoxifen is a selective estrogen receptor modulator (SERM) that blocks estrogen receptors.
   
   

3. Is Letrozole stable for tablet formulation?
   

   Yes, it offers excellent stability in film-coated tablet formulations.