Hydrochlorothiazide | 58-93-5

Description :

Overview of Hydrochlorothiazide

Hydrochlorothiazide is a synthetic pharmaceutical active ingredient belonging to the thiazide class of diuretics. It is widely used as an antihypertensive and diuretic agent in solid oral dosage forms. As a pharma chemical, Hydrochlorothiazide is produced with strict control over purity, polymorphism, and particle characteristics to meet pharmacopeial specifications.

In pharmaceutical manufacturing, Hydrochlorothiazide is valued for its chemical stability, well-characterised structure, and consistent performance in formulation development. It is commonly supplied as an API for use in single-entity and fixed-dose combination products.

Applications of Hydrochlorothiazide

Pharmaceutical API & Formulation Use

Hydrochlorothiazide is used as an active pharmaceutical ingredient in the manufacture of tablets and combination antihypertensive formulations. It is frequently formulated with other cardiovascular APIs to enhance therapeutic efficacy.

Its predictable physicochemical properties support reliable blending, granulation, and compression during large-scale pharmaceutical production.

Pharmaceutical Chemistry & Chemical Characteristics

From a pharmaceutical chemistry perspective, Hydrochlorothiazide is a benzothiadiazine sulfonamide derivative. The hydrochlorothiazide structure contains a sulfonamide group and a chloro-substituted aromatic ring, which are essential for its diuretic activity.

The chemical name of Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide.

Industrial & Regulated Manufacturing Use

Hydrochlorothiazide is manufactured under GMP conditions for regulated pharmaceutical markets. Control of impurities, residual solvents, and particle size distribution is critical to ensure batch consistency and regulatory compliance.

Safety & Handling Guidelines

• Store in a cool, dry, and well-ventilated area
• Protect from moisture and excessive heat
• Keep containers tightly sealed and clearly labelled
• Avoid inhalation of dust during handling
• Use appropriate PPE, including gloves and eye protection
• Handle under controlled pharmaceutical manufacturing conditions
• Dispose of waste according to regulatory guidelines
  
  
  

Where to Buy Hydrochlorothiazide?

Hydrochlorothiazide Manufacturer

Hydrochlorothiazide is manufactured as a pharmaceutical API where high purity, controlled synthesis, and compliance with pharmacopeial standards are essential for downstream formulation.

Hydrochlorothiazide Supplier & Distributor

Hydrochlorothiazide is supplied in pharmaceutical-grade packaging suitable for formulation manufacturers. As a pharmaceutical chemicals supplier and distributor, Chemicalbull Pvt. Ltd. supports customers with reliable sourcing and standard regulatory documentation.

MSDS for Hydrochlorothiazide

The MSDS for Hydrochlorothiazide provides detailed information on chemical hazards, handling precautions, storage requirements, exposure controls, and emergency procedures. Always review the MSDS before pharmaceutical manufacturing use.

Frequently Asked Questions (FAQs)

1. What is Hydrochlorothiazide used for in pharmaceuticals?
   

   Hydrochlorothiazide is used as an API in antihypertensive and diuretic pharmaceutical formulations.
   
   

2. What is the chemical class of Hydrochlorothiazide?
   

   Hydrochlorothiazide belongs to the thiazide diuretic class and is a benzothiadiazine sulfonamide derivative.
   
   

3. Is Hydrochlorothiazide supplied as an API?
   

   Yes, Hydrochlorothiazide is widely supplied as a pharmaceutical active ingredient for finished dosage formulation.