Diisopropylethylamine | 7087-68-5

Description :

Overview of Diisopropylethylamine

Diisopropylethylamine (DIPEA, Hunig's base) is a sterically hindered tertiary amine widely used as a non-nucleophilic base in organic synthesis and pharmaceutical manufacturing. The most well-known feature of DIPEA is its simplicity, with no nucleophilicity. DIPEA can be used for the deprotonation process, coupling reactions and also as a neutralising agent for acids during different chemical processes.

This chemical appears as an uncoloured liquid that has the characteristic odour of amine fishy. The bulky structure blocks nucleophilic reactions and provides an efficient method of removing a proton.

The products that are related to include Triethylamine Diisopropyl Ether DBU, as well as other bases that hinder organic chemical synthesis.

Applications of Diisopropylethylamine

Pharmaceutical Synthesis

• Uses to make a non-nucleophilic basis for drug chemical synthesis
• It is used in the peptide coupling reaction
• It is used in the formation of amide bonds
• It is used to safeguard the chemistry of groups
• Utilised in API manufacturing methods
• Utilised in the synthesis of pharmaceutical intermediates

Organic Synthesis

• It is used in reactions mediated by bases when nucleophilicity should not be desired.
• It is used in Mitsunobu reactions
• Utilised for Heck and in other reactions that are catalysed by palladium.
• Used in eliminations and deprotonations
• It is used to prepare the enolates, as well as various intermediates
• Used in the synthesis of heterocyclic compounds

Industrial Applications

• Utilised as an acid scavenger during the chemical process
• It is used in the manufacture of speciality chemicals
• It is used in the synthesis of agrochemicals
• It is used in dye production and the manufacturing of pigments
• Utilised in the manufacture of performance chemicals

Safety and Handling Guidelines

• Flammable liquids and vapors
• Corrosive causes skin and eye burns
• Beware of inhaling vapours
• Make sure you wear gloves, goggles, and appropriate clothes
• Handle inside a ventilated fume hood
• Storage in tightly sealed containers far from direct heat
• Stay clear of the oxidisers and strong acids.
• Be sure to follow COA and MSDS guidelines completely.

Where to Buy Diisopropylethylamine?

Diisopropylethylamine Manufacturer

ChemicalBull supplies high-purity Diisopropylethylamine (DIPEA), meeting pharmaceutical and research quality standards.

Diisopropylethylamine Supplier & Distributor

• In bulk quantities for research and pharmaceutical companies.
• Grades with high purity (99 per cent, 99.5%)
• Chemical and technical grades
• COA MSDS, along with specifications, is provided.

MSDS

With detailed safety information, corrosivity information and procedures for handling.

Frequently Asked Questions (FAQs)

1. What is Diisopropylethylamine used for?
   

   Used as a non-nucleophilic base in peptide coupling, pharmaceutical synthesis, palladium-catalysed reactions, and various organic transformations.
   
   

2. What is DIPEA molecular formula?
   

   Chemical formula: C₈H₁₉N or (iPr)₂NEt with molecular weight 129.24 g/mol.
   
   

3. Why is DIPEA called Hünig's base?
   

   Named after chemist Siegfried Hünig, who systematically studied its properties and applications in organic synthesis.