Diethyl Chlorophosphate | 814-49-3

Description :

Overview of Diethyl Chlorophosphate

Diethyl Chlorophosphate is an organophosphorus compound that can be used to phosphorylate reagents, chemical intermediates, and for organic syntheses. It is renowned for its outstanding ability to phosphorylate and its reactivity. Diethyl Chlorophosphate is used extensively to synthesise pharmaceuticals, agrochemicals, and organophosphate compounds.

The chemical appears as a transparent to light yellow liquid, with typical phosphate ester properties. The phosphorochloridic structure of the ester provides the ability to phosphorylate many organic nucleophiles.

Similar products are Diethyl Phosphate, Phosphorus Oxychloride, Diethyl Maleate, as well as other phosphorylating substances that are used in agrochemical and pharmaceutical syntheses.

Applications of Diethyl Chlorophosphate

Pharmaceutical Synthesis

• It is used to phosphorylate reagents in the process of drug production
• Utilised in the production of pharmaceutical intermediates
• It is used in the synthesis of prodrugs that contain Phosphate groups
• Used in nucleotide and nucleoside Chemistry
• Used in preparing organophosphate-based drugs
• Applied in enzyme inhibitor synthesis

Organic Synthesis

• Utilised to perform O-phosphorylation reactions
• Used in N-phosphorylation, the amines
• Utilized to activate carboxylic acids
• Used in the preparation of Enolphosphates
• Used in Horner-Wadsworth-Emmons reactions
• Applied in synthesising phosphonate esters

Application of Agrochemicals

• It is used in the synthesis of pesticides made from organophosphates
• It is used in manufacturing insecticides
• It is used in the preparation of intermediates for herbicides
• Applied in developing crop protection products
• Utilised in chemical agricultural research

Safety and Guidelines for Handling

• CORROSIVE AND TOXIC - handle with care
• Reacts to moisture, so use anhydrous conditions
• Use gloves, goggles, a face shield, and protective clothing
• Handle within a well-ventilated fume Hood
• Keep in tightly sealed, dry containers
• Beware of bases, water, as well as alcohols
• Have an emergency shower/eyewash available
• Use the COA as well as the MSDS directions completely

Where to Buy Diethyl Chlorophosphate?

Diethyl Chlorophosphate Manufacturer

ChemicalBull supplies high-purity Diethyl Chlorophosphate, meeting pharmaceutical and research quality standards.

Diethyl Chlorophosphate Supplier & Distributor

• Available in controlled quantities for pharmaceutical and research use
• High-purity anhydrous grade (97%, 99%)
• Special moisture-resistant packaging
• COA, MSDS, and safety documentation provided

MSDS

Includes comprehensive safety instructions, reactivity information, and emergency procedures.

Frequently Asked Questions (FAQs)

1. What is Diethyl Chlorophosphate used for?
   

   Used as a phosphorylating reagent in pharmaceutical synthesis, organic chemistry, and agrochemical manufacturing.
   
   

2. What is the chemical formula?
   

   Molecular formula: C₄H₁₀ClO₃P with molecular weight 172.55 g/mol.
   
   

3. How does it work as a phosphorylating agent?
   

   Electrophilic phosphorus reacts with nucleophiles (alcohols, amines, carbanions), displacing chloride, introducing a phosphate ester group.