1-Bromo-4-Fluorobenzene | 460-00-4

Description :

Overview of 1-Bromo-4-Fluorobenzene

1-Bromo-4-Fluorobenzene (CAS: 460-00-4) is a halogenated aromatic compound widely used as an intermediate in pharmaceuticals, agrochemicals, and specialty chemical synthesis. It appears as a colorless to pale yellow liquid with excellent chemical stability and reactivity toward nucleophilic substitution and cross-coupling reactions.

Valued for its bromine and fluorine substituents, it is frequently used in Suzuki, Heck, and other palladium-catalyzed reactions to produce complex aromatic derivatives. Its applications include the preparation of fine chemicals, active pharmaceutical ingredients (APIs), and advanced materials.

Related products available on ChemicalBull: 1-Bromobenzene, 4-Fluorobenzaldehyde, Bromobenzene derivatives – commonly used in halogenated intermediates, pharmaceutical synthesis, and organic chemistry research.

Applications of 1-Bromo-4-Fluorobenzene

Pharmaceutical Intermediates

• Key intermediate for API synthesis

• Used in the preparation of halogenated drug molecules

• Applied in medicinal chemistry research and pharmaceutical R&D

Organic Synthesis & Cross-Coupling Reactions

• Suitable for Suzuki, Heck, and Sonogashira coupling

• Used to produce substituted aromatic compounds

• Applied in specialty chemical and fine chemical manufacturing

Agrochemical & Specialty Chemicals

• Intermediate in the synthesis of herbicides, pesticides, and fungicides

• Supports production of halogenated functional compounds

• Used in research and industrial development of agrochemical derivatives

Laboratory & Analytical Applications

• Used in small-scale lab reactions for developing novel molecules

• Supports academic and industrial chemical research

• Applied in the preparation of halogenated aromatic standards

Safety & Handling Guidelines

• Flammable and reactive with strong bases

• Wear gloves, goggles, and protective clothing

• Handle in a well-ventilated area or fume hood

• Store in tightly sealed containers away from heat and oxidizing agents

• Follow COA and MSDS guidelines strictly

Where to Buy 1-Bromo-4-Fluorobenzene?

1-Bromo-4-Fluorobenzene Manufacturer

ChemicalBull supplies high-purity 1-Bromo-4-Fluorobenzene for pharmaceutical, agrochemical, and fine chemical synthesis.

1-Bromo-4-Fluorobenzene Supplier & Distributor

• Available in bulk and laboratory-scale packaging

• Suitable for cross-coupling reactions, API synthesis, and specialty chemical manufacturing

• COA, MSDS, and technical specifications provided

1-Bromo-4-Fluorobenzene MSDS

• Flammable liquid; may cause skin and eye irritation

• Use PPE and avoid inhalation of vapors

• Handle in ventilated areas; prevent exposure to sparks or heat

• Store away from acids, oxidizers, and incompatible substances

• Refer to full MSDS for detailed handling, spill control, and emergency procedures

Frequently Asked Questions (FAQs)

1. What is the molecular formula of 1-Bromo-4-Fluorobenzene?

   Molecular Formula: C₆H₄BrF
   Molecular Weight: 157.00 g/mol
   
   

2. What is 1-Bromo-4-Fluorobenzene used for?

   Used as a halogenated intermediate in pharmaceuticals, agrochemicals, organic synthesis, and cross-coupling reactions.
   
   

3. Is 1-Bromo-4-Fluorobenzene hazardous?

   Flammable and irritant; handle with proper PPE and follow MSDS instructions.