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A class of antidepressant drugs known as serotonin-norepinephrine reuptake inhibitors, or SNRIs, is frequently prescribed to treat anxiety disorders, depression, and other illnesses. They function by raising the brain's concentrations of serotonin and norepinephrine, two neurotransmitters important for mood regulation and the stress response. This is a quick synopsis of SNRIs:Mechanism of Action: SNRIs function by preventing serotonin and norepinephrine from being reabsorbed by the presynaptic neuron. This implies that a greater quantity of these neurotransmitters are accessible in the synaptic cleft that separates neurons, amplifying their impact on mood regulation.Indications: The main condition for which SNRIs are utilized is major depressive disorder (MDD). Additionally, they are given for panic disorder, social anxiety disorder, generalized anxiety disorder (GAD), and a few chronic pain diseases like neuropathic pain and fibromyalgia. As an illustration: One of the SNRIs that is most frequently administered is venlafaxine (Effexor). Both immediate-release and extended-release versions are offered. Duloxetine: Also known as Cymbalta: Often prescribed for anxiety, depression, and several pain syndromes. There are delayed-release capsules available as well. Desvenlafaxine, also known as Pristiq, is the active metabolite of venlafaxine and a more recent SNRI. MDD is also treated using it. Adult MDD patients are approved to use levomilnacipran (Fetzima). Its structure is comparable to that of venlafaxine, but its effect on norepinephrine reuptake is more selective.Side Effects: Nausea, dry mouth, lightheadedness, sleeplessness, constipation, and increased perspiration are typical SNRI side effects. These negative effects usually subside with time and are frequently temporary. Monitoring is crucial since SNRIs can raise blood pressure as well, particularly in individuals who already have hypertension. Withdrawal: Sudden cessation of SNRIs may result in withdrawal symptoms, including headache, nausea, irritability, and flu-like symptoms. To reduce these side effects, it's critical to taper off these medications under physician supervision. Warnings: Because SNRIs can cause manic episodes, they may not be appropriate for everyone, especially those with a history of bipolar disorder. They might also interact with other prescriptions, so it's important to let medical professionals know about all the medications you take.To sum up, SNRIs are effective drugs for treating anxiety disorders, depression, and some types of pain. However, they should only be used under a doctor's supervision and require close monitoring for adverse effects.