A Schedule III controlled substance is a type of drug that has a moderate to low potential for abuse and ... A Schedule III controlled substance is a type of drug that has a moderate to low potential for abuse and dependence but is currently accepted for medical use in the United States. Some examples of Schedule III drugs are ketamine, anabolic steroids, and buprenorphine. These drugs are regulated by the Drug Enforcement Administration (DEA) and require a prescription from a licensed practitioner. Schedule III drugs are less dangerous than Schedule I and II drugs, which have a high potential for abuse and no accepted medical use, but more dangerous than Schedule IV and V drugs, which have a low potential for abuse and dependence. Schedule III drugs may cause moderate or low physical dependence or high psychological dependence if abused. Some of the effects of Schedule III drugs may include pain relief, sedation, euphoria, increased energy, appetite suppression, or muscle growth. Schedule III drugs may also have side effects, such as nausea, vomiting, drowsiness, confusion, mood changes, or respiratory depression. Schedule III drugs may interact with other medications or substances, such as alcohol, and cause serious harm or death. Therefore, Schedule III drugs should be used only as directed by a doctor and stored securely away from children and pets.