Salicylamide is an over-the-counter medication with analgesic and antipyretic effects. It is the most basic compound in the group of salicylamides made from salicylic acid. It functions as both an antirheumatic and non-narcotic analgesic. It is a phenol and a member of the salicylamide family. Crystals of odorless, white or slightly pink salicylamide are produced. The tongue feels warm after eating it, and the flavor is bitter. At 82 °F, it has a pH of roughly 5 (saturated aqueous solution). The over-the-counter pain reliever PainAid contains aspirin, caffeine, and salicylamide in combination. It was also a component of BC Powder, an over-the-counter pain reliever, but it was eliminated from the composition in 2009. From 1960 to 1980, Excedrin utilized it in combination with aspirin, acetaminophen, and caffeine. It served as a phenacetin alternative in later Australian formulations of Vincent's powders. Ethenzamide, labetalol, medroxalol, lopirin, otilonium, oxyclozanide, salicylanilide, niclosamide, and raclopride are salicylamide derivatives. Salicylamide's exact mode of action is unknown, however it is believed to prevent the synthesis of prostaglandins, which are molecules that induce pain and inflammation. Additionally, cyclooxygenase-2 (COX-2), an enzyme involved in the generation of prostaglandins, appears to be inhibited by salicylamide. Although salicylamide is typically well accepted, it can have some undesirable side effects, including nausea, vomiting, upset stomach, and diarrhea. Some people may also experience allergic reactions to it. Salicylamide is not advised for use by pregnant or nursing mothers. Additionally, those who suffer from liver or kidney illness ought to avoid it. Consult your doctor before beginning salicylamide therapy. They can assist you in deciding if it is risk-free for you to consume and in managing any adverse effects you may encounter.
