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Rodenticides are chemical agents designed to control and manage rodent populations. These substances are employed to eradicate or limit the proliferation of rats and mice, which are common pests in various environments, including agricultural fields, urban areas, and households. Rodenticides work through diverse mechanisms, targeting the rodents' physiology to induce lethal effects. Anticoagulant rodenticides are widely used and function by interfering with the blood clotting process. They inhibit vitamin K, a crucial factor in clotting, leading to uncontrolled bleeding and eventual death. Another category includes acute toxicants like zinc phosphide, which releases toxic phosphine gas in the rodent's stomach, causing systemic failure. The deployment of rodenticides requires careful consideration to minimize unintended consequences, such as secondary poisoning of non-target species. Some rodenticides are potent enough to pose risks to predators or scavengers that may consume poisoned rodents. Additionally, there is ongoing research to develop more environmentally friendly and targeted rodent control methods, considering the broader ecological impact. Effective rodent management involves a strategic approach, combining rodenticides with preventive measures like proper sanitation and exclusion. While rodenticides play a crucial role in pest control, responsible and informed use is essential to balancing effective rodent eradication with environmental and wildlife conservation.