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Phenothiazines are heterocyclic compounds having a tricyclic structure consisting of two benzene rings and a sulfur-containing seven-membered ring. They have received a lot of interest in the medical profession because of their various pharmacological effects, particularly as antipsychotic and antiemetic drugs. Chlorpromazine is one of the most well-known phenothiazines, having revolutionized the treatment of psychiatric diseases when it was introduced in the 1950s. As the first widely used antipsychotic, chlorpromazine played a critical role in the deinstitutionalization of mental health patients. Its success led the path for the creation of further phenothiazine derivatives, including thioridazine, trifluoperazine, and fluphenazine. Phenothiazines' antipsychotic effects are due to their ability to inhibit dopamine receptors in the brain. Dopamine is a neurotransmitter that influences mood, behavior, and cognition, and disruption of its signaling has been linked to illnesses such as schizophrenia. Phenothiazines assist treat psychotic symptoms like delusions and hallucinations by antagonizing dopamine receptors. Aside from their psychiatric applications, phenothiazines have shown useful as antiemetic drugs, particularly in the treatment of nausea and vomiting caused by chemotherapy. Promethazine, for example, has been frequently utilized for this purpose because of its capacity to block dopamine receptors in the chemoreceptor trigger zone, effectively decreasing the vomiting reflex. However, the use of phenothiazines is not without complications. These chemicals have a variety of adverse effects, including drowsiness, extrapyramidal symptoms, and anticholinergic activity. Long-term use may also result in tardive dyskinesia, which is a possibly irreversible movement disease. In recent years, researchers have focused on producing novel antipsychotic drugs with higher efficacy and fewer adverse effects. Nonetheless, phenothiazines continue to be an important part of the pharmacological arsenal for treating various psychiatric and gastrointestinal diseases, demonstrating the chemicals' long-term impact on medical therapies. Ongoing research investigates innovative applications and derivatives of phenothiazines, ensuring that their contributions to medicine advance in lockstep with our understanding of neuropharmacology.